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BACKGROUND A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. A significant barrier to translational research is the lack of uniformly structured data across related biomedical domains. The Semantic(More)
At present, there are over 215 Internet-accessible databases that store biological pathway data. Biologists often need to use information from many of these to support their research, but since each has its own representation conventions and data access methods, integrating data from multiple databases is very difficult. A widely-adopted biological pathway(More)
Biological Pathway Exchange (BioPAX) is a standard language to represent biological pathways at the molecular and cellular level and to facilitate the exchange of pathway data. The rapid growth of the volume of pathway data has spurred the development of databases and computational tools to aid interpretation; however, use of these data is hampered by the(More)
The Web has become the major medium for various communities to share their knowledge. To this end, it provides an optimal environment for knowledge networks. The web offers global connectivity that is virtually instantaneous, and whose resources and documents can easily be indexed for easy searching. In the coupled realms of biomedical research and(More)
BioPAX (Biological Pathway Exchange) is a standard language to represent biological pathways at the molecular and cellular level. Its major use is to facilitate the exchange of pathway data (http://www.biopax.org). Pathway data captures our understanding of biological processes, but its rapid growth necessitates development of databases and computational(More)
The BioPAX data exchange format is the joint work of the BioPAX workgroup and Level 3 builds on the work of Level 2 and Level 1. Thanks to the many additional people who contributed to discussions 1 on the various BioPAX mailing lists and at BioPAX meetings. Abstract There are over 300 Internet-accessible databases that store biological pathway data.(More)
Objective: To evaluate the efficacy of a commercial porcine circovirus type 2 (PCV2) vaccine in reducing postweaning mortality in a multi-site field setting. Materials and methods: In 2007, a PCV2 vaccine recommended for use in piglets ≥ 4 weeks of age was made available in New Zealand for control of porcine circovirus associated disease (PCVAD). The(More)
Pharmacogenomics is a key factor that will drive the personalized medicine vision. It will help create new combinations of clinical and genomic information necessary for making clinical decision in personalized medicine. Much can be done using available public data sources, yet they lack essential facts that can be only obtained from deep focused curation.(More)
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