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Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is the signature event in pancreatic ductal adenocarcinoma (PDAC), serving a critical role in tumor initiation. Here, an inducible Kras(G12D)-driven PDAC mouse model establishes that advanced PDAC remains(More)
Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis to drive progressive atrophy and functional decline in high-turnover tissues. The broader adverse impact of telomere dysfunction across many tissues including more quiescent systems prompted transcriptomic network analyses to identify common mechanisms operative in(More)
BACKGROUND Functional brain imaging studies in major depression have suggested abnormalities of areas, including the frontal cortex, cingulate gyrus, basal ganglia, and temporal cortex. We hypothesized that venlafaxine hydrochloride and interpersonal psychotherapy (IPT) might each alter brain blood flow in some or all of these areas on sequential single(More)
Digital Imaging and Communication in Medicine (DICOM) has become one of the most popular standards in medicine. In the beginning, DICOM was used for communication of image data between different systems. Actual developments of the standardisation enables increasingly more DICOM-based services for the integration of modalities and information systems (e.g.(More)
The TCL1 gene at 14q32.1 is involved in chromosomal translocations and inversions in mature T cell leukemias. These leukemias are classified either as T prolymphocytic leukemias, which occur very late in life, or as T chronic lymphocytic leukemias, which often arise in patients with ataxia telangiectasia (AT) at a young age. In transgenic animals, the(More)
Colorectal cancer (CRC) is a major cause of cancer morbidity and mortality, and elucidation of its underlying genetics has advanced diagnostic screening, early detection, and treatment. Because CRC genomes are characterized by numerous non-random chromosomal structural alterations, we sought to delimit regions of recurrent amplifications and deletions in a(More)
[1] Thirty-three snowpack models of varying complexity and purpose were evaluated across a wide range of hydrometeorological and forest canopy conditions at five Northern Hemisphere locations, for up to two winter snow seasons. Modeled estimates of snow water equivalent (SWE) or depth were compared to observations at forest and open sites at each location.(More)
A new link-based document ranking framework is devised with at its heart, a contents and time sensitive random literature explorer designed to more accurately model the behaviour of readers of scientific documents. In particular, our ranking framework dynamically adjusts its random walk parameters according to both contents and age of encountered documents,(More)
Soil moisture is a key parameter in different environmental applications, such as hydrology and natural risk assessment. In this paper, surface soil moisture mapping was carried out over a basin in France using satellite synthetic aperture radar (SAR) images acquired in 2006 and 2007 by C-band (5.3 GHz) sensors. The comparison between soil moisture(More)
Space manipulators mounted on a on-o thruster-controlled b ase are envisioned to assist in the assembly and maintenance o f s p ace structures. When handling large payloads, manipulator joint and link ex-ibility become important, for it can result in payload-attitude controller fuel-replenishing dynamic interactions. In this paper, the dynamic behavior of a(More)