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Transient high-frequency (100-500 Hz) oscillations of the local field potential have been studied extensively in human mesial temporal lobe. Previous studies report that both ripple (100-250 Hz) and fast ripple (250-500 Hz) oscillations are increased in the seizure-onset zone of patients with mesial temporal lobe epilepsy. Comparatively little is known,(More)
OBJECTIVE Recent studies indicate that pathologic high-frequency oscillations (HFOs) are signatures of epileptogenic brain. Automated tools are required to characterize these events. We present a new algorithm tuned to detect HFOs from 30 to 85 Hz, and validate it against human expert electroencephalographers. METHODS We randomly selected 28 3-min(More)
Localizing epileptic networks is a central challenge in guiding epilepsy surgery, deploying antiepileptic devices, and elucidating mechanisms underlying seizure generation. Recent work from our group and others suggests that high-frequency epileptic oscillations (HFEOs) arise from brain regions constituting epileptic networks, and may be important to(More)
Localizing an epileptic network is essential for guiding neurosurgery and antiepileptic medical devices as well as elucidating mechanisms that may explain seizure-generation and epilepsy. There is increasing evidence that pathological oscillations may be specific to diseased networks in patients with epilepsy and that these oscillations may be a key(More)
— The application of feature selection techniques greatly reduces the computational cost of classifying high-dimensional data. Feature selection algorithms of varying performance and computational complexities have been studied previously. This paper compares the performance of classical sequential methods, a floating search method, and the " globally(More)
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