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STUDY DESIGN A cadaveric study. OBJECTIVE To define the relationship of the lumbar exiting nerve root and trunks within the psoas muscle with reference to the radiographic center of the intervertebral disc, the recommended disc access point for the minimally invasive lateral transpsoas approach. SUMMARY OF BACKGROUND DATA The transpsoas approach to the(More)
Mechanisms of cardiac excitation-contraction coupling in neonates are still not clearly defined. Previous work in neonates shows reverse-mode Na(+)-Ca(2+) exchange to be the primary route of Ca(2+) entry during systole and the neonatal sarcoplasmic reticulum to have similar capability as that of adult in storing and releasing Ca(2+). We investigated(More)
OBJECTIVE Acute lung injury and acute respiratory distress syndrome have been reported in a significant proportion of patients with critical neurologic illness. Our aim was to identify risk factors for acute lung injury/acute respiratory distress syndrome in this population. DESIGN Prospective, observational study. SETTING A 22-bed, adult neurosciences(More)
Spinal fusion remains the gold standard for surgical management of instability and mechanical low back or neck pain. However, even in carefully selected patients, successful clinical results can be difficult to achieve. Reasons for failure include pseudarthrosis and adjacent spine segment disease. The theoretic advantages of removing the painful disk while(More)
To exploit fully the potential of current sequencing technologies for population-based studies, one must enrich for loci from the human genome. Here we evaluate the hybridization-based approach by using oligonucleotide capture probes in solution to enrich for approximately 3.9 Mb of sequence target. We demonstrate that the tiling probe frequency is(More)
In adult cardiac cells the established mechanism of excitation-contraction coupling is by calcium-induced calcium release (CICR) mediated by L-type Ca(2+) channels. However, in neonate cardiomyocytes, a CICR modality involving reverse mode Na(+)-Ca(2+) exchanger (NCX) activity predominates. This has been hypothesized to be due, in part, to the high(More)
BACKGROUND CONTEXT Several methods to sterilize allograft bone exist, including gamma irradiation and freeze-drying, which can alter the mechanical properties of the graft. Efforts are under way to develop a method for processing osseous allograft that maintains structural integrity. Herein is presented one such method. PURPOSE To analyze the mechanical(More)
The zebrafish (Danio rerio) has emerged as an important model for developmental cardiovascular (CV) biology; however, little is known about the cardiac function of the adult zebrafish enabling it to be used as a model of teleost CV biology. Here, we describe electrophysiological parameters, such as heart rate (HR), action potential duration (APD), and(More)
Managed Runtime Environments (MRTEs) such as the Java platform promise a cross platform "Write Once, Deploy Anywhere" mechanism. However, MRTE applications that contain native method calls are not seamlessly portable across platforms. In this paper, we describe a new approach to transparently run Java applications containing native method calls to one ISA(More)