Eric L. Null

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Much progress has been made in designing metalloproteins with structures similar to native enzymes [1] and advances in computational biology have allowed for rational design of enzyme function as well. [2] Despite these achievements, most designed enzymes have simple active site structures and low activities, with limited turnover numbers. Designing(More)
The natural chirality of DNA and RNA aptamers has been used to develop fluorescent agents to determine the enantiomeric ratio of adenosine and arginine, respectively. The quantification is based on structure-switching DNA or RNA aptamers labeled with fluorophore and quencher, allowing chiral detection down to 0.1 : 99.9 (L : D) for arginine after(More)
DNAzymes are known to bind metal ions specifically to carry out catalytic functions. Despite many studies since DNAzymes were discovered nearly two decades ago, the metal-binding sites in DNAzymes are not fully understood. Herein, we adopt uranyl photocleavage to probe specific uranyl-binding sites in the 39E DNAzyme with catalytically relevant(More)
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