Eric L. Null

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Much progress has been made in designing metalloproteins with structures similar to native enzymes and advances in computational biology have allowed for rational design of enzyme function as well. Despite these achievements, most designed enzymes have simple active site structures and low activities, with limited turnover numbers. Designing artificial(More)
DNAzymes are known to bind metal ions specifically to carry out catalytic functions. Despite many studies since DNAzymes were discovered nearly two decades ago, the metal-binding sites in DNAzymes are not fully understood. Herein, we adopt uranyl photocleavage to probe specific uranyl-binding sites in the 39E DNAzyme with catalytically relevant(More)
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