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In vitro assessment of cytotoxicity based on electrochemical impedance spectroscopy (EIS) needs more quantitative methods to analyze the alteration of cell morphology and motility, and hence the potential risk to human health. Here, we applied electric cell-substrate impedance sensing (ECIS) to evaluate dose-dependent responses of human umbilical vein(More)
A central challenge in human computation is in understanding how to design task environments that effectively attract participants and coordinate the problem solving process. In this paper, we consider a common problem that requesters face on Amazon Mechanical Turk: how should a task be designed so as to induce good output from workers? In posting a task, a(More)
In this paper we present a system which uses ontological resources and a gene name variation generation tool to expand concepts in the original query. The novelty of our approach lies in our concept-based normal-ization ranking model. For the 2007 Ge-nomic task, we also modified this system architecture with an additional dynamic form of query expansion(More)
To understand the diversity in the cell culture harvest (i.e., feedstock) provided for downstream processing, we compared host cell protein (HCP) profiles using three Chinese Hamster Ovary (CHO) cell lines in null runs which did not generate any recombinant product. Despite differences in CHO lineage, upstream process, and culture performance, the cell(More)
Activated macrophages play a central role in antitumor immunity. However, the stimuli that activate macrophages to kill tumor cells are not completely understood. Because the center of solid tumors can be hypoxic, we hypothesized that hypoxia may be an important signal in activating macrophages to kill tumor cells. Hypoxia stimulates IFN-primed macrophages(More)
After their first encounter with a foreign antigen, naïve B cells that have immunoglobulin M (IgM) B cell receptors (BCRs) trigger the primary antibody response and the generation of memory B cells with IgG BCRs. When these memory B cells reencounter the same antigen, the cell surface IgG BCRs stimulate their rapid differentiation into plasma cells that(More)