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Atorvastatin has been shown to reduce coronary events and revascularization procedures in patients with multiple risk factors for coronary heart disease. Recent studies with atorvastatin 80 mg support the overall safety of this dose during long-term treatment. However, physicians appear reluctant to use high doses of statins. A retrospective analysis of(More)
INTRODUCTION Ankylosing spondylitis (AS) is a chronic rheumatic disease associated with spinal inflammation that subsequently leads to progression of structural damage and loss of function. The fully human anti-tumor necrosis factor (anti-TNF) antibody adalimumab reduces the signs and symptoms and improves overall quality of life in patients with active AS;(More)
AIMS More than half of infants exposed to opioids in utero develop neonatal abstinence syndrome (NAS) of severity to require pharmacological therapy. Current treatments are associated with prolonged hospitalization. We sought to optimize the dose of sublingual buprenorphine in the treatment of NAS. DESIGN Randomized, Phase 1, open-label, active-control(More)
OBJECTIVE In utero exposure to drugs of abuse can lead to neonatal abstinence syndrome, a condition that is associated with prolonged hospitalization. Buprenorphine is a partial mu-opioid agonist used for treatment of adult detoxification and maintenance but has never been administered to neonates with opioid abstinence syndrome. The primary objective of(More)
OBJECTIVE To evaluate the effect of sweet taste stimulation in augmenting the reported growth-enhancing effects of nonnutritive sucking in preterm infants who are gavage-fed. DESIGN Random assignment of preterm infants to receive stimulation by one of three methods during each feeding until totally orally fed. SETTING Hospital intensive-care and infant(More)
We compared 4 measures of abdominal muscle strength in 24 male subjects aged 20-52 years, 12 without low back pain (LBP) and 12 with LBP. The manometer to knee and manometer to sternum methods involved 2 positions of testing abdominal muscle strength using the adapter sphygmomanometer, a 3rd method was a scheme of graduated sit-ups, and the 4th had the(More)