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BACKGROUND Parkinson's disease (PD) is histopathologically characterized by the loss of dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well as the neural fibers that link the substantia nigra to the striatum (putamen and caudate), causing(More)
BACKGROUND This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and(More)
In this thesis, we consider the clustering of time series data; specifically, time series that can be modeled in the state space framework. Of primary focus is the pairwise discrepancy between two state space time series. The state space model can be formulated in terms of two equations: the state equation, based on a latent process, and the observation(More)
NOAA (National Oceanic and Atmospheric Administration)-LEO environmental satellites provide continuous coverage of Earth, supplying high-resolution global meteorological, oceanic and space observation data. In addition, these satellites are part of the international COSPAS – SARSAT program, which aides search and rescue teams worldwide. The USA segment,(More)
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