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DNA methylation has been traditionally viewed as a highly stable epigenetic mark in postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation changes, at least in a few identified CpG dinucleotides. How extensively the neuronal DNA methylome is regulated by neuronal activity is unknown. Using a next-generation sequencing-based(More)
Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously(More)
We describe a method for generating CT images at multiple respiratory phases with a single spiral CT scan, referred to as respiratory-correlated spiral CT (RCCT). RCCT relies on a respiration wave form supplied by an external patient monitor. During acquisition this wave form is recorded along with the initiation time of the CT scan, so as to "time stamp"(More)
We measure simultaneously the properties of the energy spectra and the frequencies of the kilohertz quasi-periodic oscillations (QPOs) in fifteen low mass X-ray binaries covering a wide range of X-ray luminosities. In each source the QPO frequencies cover the same range of approximately 300 Hz to 1300 Hz, though the sources differ by two orders of magnitude(More)
We present new results based on observations carried out with the Rossi X-ray Timing Explorer during the decay of an outburst of the low-mass X-ray binary (LMXB) and atoll source 4U 1608–52. Our results appear to resolve, at least in 4U 1608–52, one of the long-standing issues about the phenomenology of the kilohertz quasi-periodic oscillations (kHz QPOs),(More)
We investigate the behavior of the high frequency quasi-periodic oscillations (QPOs) in 4U 0614+091, combining timing and spectral analysis of RXTE observations. The energy spectra of the source can be described by a power law (α ∼ 2.8) and a blackbody (kT ∼ 1.5), with the blackbody accounting for 10–20% of the total energy flux. We find a robust(More)
It remains difficult to distinguish tumor recurrence from radiation necrosis after brain tumor therapy. Here we show that these lesions can be distinguished using the amide proton transfer (APT) magnetic resonance imaging (MRI) signals of endogenous cellular proteins and peptides as an imaging biomarker. When comparing two models of orthotopic glioma(More)
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder resulting from CAG repeat expansion in the gene that encodes for the protein huntingtin. To identify neuroprotective compound (s) that can slow down disease progression and can be administered long term with few side effects in Huntington's disease, we investigated the effect(More)
Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. (18)F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this(More)
Shifts in attention were examined in patients with Huntington's disease (HD) using a divided attention paradigm that involved the presentation of global-local stimuli. The HD patients' pattern of performance was compared to the previously reported results of groups of patients with Alzheimer's disease (AD; Filoteo et al., 1992) or Parkinson's disease (PD;(More)