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OBJECTIVE To determine if lowering of serum uric acid (SUA) concentrations below 6 mg/dl or longer duration of lowered SUA will result in depletion of urate crystals from the knee joints and prevent further attacks of gout. METHODS A prospective study was initiated 10 years ago at Philadelphia VA Medical Center to attempt to maintain SUA levels of(More)
Humeral medial epicondyle fractures in the pediatric population account for up to 20% of elbow fractures, 60% of which are associated with elbow dislocation. Isolated injuries can occur from either direct trauma or avulsion. Medial epicondyle fractures also occur in combination with elbow dislocations. Traditional management by cast immobilization(More)
The author hereby grants to M.I.T. permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole and in part in any medium now known or hereafter created. ABSTRACT To more accurately predict which genes from different species have the same function (orthologs), I extend the network-alignment algorithm(More)
OBJECTIVE To demonstrate posttraumatic chondrocyte apoptosis in the murine xiphoid after a crush-type injury and to ultimately determine the pathway (i.e., intrinsic or extrinsic) by which chondrocytes undergo apoptosis in response to mechanical injury. DESIGN The xiphoids of adult female wild-type mice were injured with the use of a modified Kelly clamp.(More)
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