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  • Flavio Solca, Goeran Dahl, +7 authors Guenther R. Adolf
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental…
  • 2012 (First Publication: 1 November 2012)
  • Deregulation of the ErbB (proto-oncogene B of the avian erythroblastosis virus AEV-H strain) receptor network is well recognized as an oncogenic driver in epithelial cancers. Several targeted drugsContinue Reading
  • Michael Demel, Oliver H. Krämer, Peter Ettmayer, Eric Dr Haaksma, Gerhard F. Ecker
  • Chemistry, Medicine
  • Molecular informatics
  • 2010 (First Publication: 15 March 2010)
  • Within the last decades, the detailed knowledge on the impact of membrane bound drug efflux transporters of the ATP binding cassette (ABC) protein family on the pharmacological profile of drugs hasContinue Reading
  • Michael P. Sanderson, Joshua Apgar, +12 authors Norbert Kraut
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2015 (First Publication: 1 December 2015)
  • Inhibition of the IGF1R, INSRA, and INSRB receptor tyrosine kinases represents an attractive approach of pharmacologic intervention in cancer, owing to the roles of the IGF1R and INSRA in promotingContinue Reading