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- Eric D. Smith, Harold J. Morowitz
- Proceedings of the National Academy of Sciencesâ€¦
- 2004

We analyze the stoichiometry, energetics, and reaction concentration dependence of the reductive tricarboxylic acid (rTCA) cycle as a universal and possibly primordial metabolic core. The rTCAâ€¦ (More)

- Daniel J. Hruschka, Simon Branford, +4 authors Tanmoy Bhattacharya
- Current Biology
- 2015

BACKGROUND
Concerted evolution is normally used to describe parallel changes at different sites in a genome, but it is also observed in languages where a specific phoneme changes to the same otherâ€¦ (More)

- Eric D. Smith
- Physical review. E, Statistical, nonlinear, andâ€¦
- 2005

It is often assumed that maximization of the statistical entropy cannot account for the spontaneous emergence of currents or compositional heterogeneity associated with them, and that otherâ€¦ (More)

- Eric D. Smith
- Physical review. E, Statistical, nonlinear, andâ€¦
- 2008

Many of the core concepts and (especially field-theoretic) tools of statistical mechanics have developed within the context of thermodynamic equilibrium, where state variables are all taken to beâ€¦ (More)

- Eric D. Smith
- Journal of theoretical biology
- 2008

This is the first of three papers analyzing the representation of information in the biosphere, and the energetic constraints limiting the imposition or maintenance of that information. Biologicalâ€¦ (More)

- Eric D. Smith
- Physical review. E, Statistical, nonlinear, andâ€¦
- 2003

The self-organization of a classical current is studied, in an exactly solvable model where both the quantum statistics over microhistories of particles, and the macroscopic phenomenology, can beâ€¦ (More)

- Supriya Krishnamurthy, Eric D. Smith, David B. Krakauer, Walter Fontana
- Biology Direct
- 2007

Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation and dephosphorylation with feedback. The circuit consists of a kinaseâ€¦ (More)

- Eric D. Smith, Supriya Krishnamurthy, Walter Fontana, David B. Krakauer
- Physical review. E, Statistical, nonlinear, andâ€¦
- 2011

We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite ofâ€¦ (More)

- Eric D. Smith, Supriya Krishnamurthy
- Physical review. E
- 2017

Stochastic chemical reaction networks (CRNs) are complex systems that combine the features of concurrent transformation of multiple variables in each elementary reaction event and nonlinear relationsâ€¦ (More)

- Eric D. Smith, June Tome, +5 authors Adam Helms
- International journal of cardiology
- 2018

OBJECTIVE
To determine whether abnormal blood pressure response (ABPR), with or without left ventricular outflow tract obstruction (LVOTO), is associated with adverse heart failure and arrhythmiaâ€¦ (More)