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In Parkinson’s disease (PD), there is increasing evidence for disorders in the impulsive-compulsive spectrum, related to the disease itself, to the pharmacological management of this disease or to both. These disorders comprise dopamine deficiency syndrome (with immediate reward seeking behaviour), dopamine dependency syndrome (with addictive behaviour),(More)
OBJECTIVE To assess the influence of rigidity and bradykinesia and the extent of dopaminergic degeneration on interlimb coordination during walking in early, drug-naive patients with Parkinsons disease (PD). DESIGN The interlimb coordination was examined during a systematic manipulation of walking speed on a treadmill. The phase relations between arm and(More)
A polymerase chain reaction with nested primer pairs based on the DNA sequence of the 39-kDa bmp gene of Treponema pallidum subsp. pallidum is described. The method allowed the detection of purified T. pallidum DNA equivalent to the amount of DNA in a single bacterium and was specific for T. pallidum subspecies. After concentration of DNA, using(More)
Sirs: In their review on bilateral ballism, Hoogstraten et al, [4] mentioned the possible aetiological role of the hormonal status of a patient. We report the case of a 28-year-old patient who showed a paraballistic syndrome, which developed after she had taken oral contraceptives. She was admitted to the neurological department because of gradually(More)
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