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BACKGROUND Computer simulation models are used increasingly to support public health research and policy, but questions about their quality persist. The purpose of this article is to review the principles and methods for validation of population-based disease simulation models. METHODS We developed a comprehensive framework for validating population-based(More)
BACKGROUND Osteoarthritis (OA) has a significant impact on individuals' ability to work. Our goal was to investigate the effects of the site of OA (knee, hip, hand, foot, lower back or neck) on employment reduction due to OA (EROA). METHODS AND FINDINGS This study involved a random sample of 6,000 patients with OA selected from the Medical Service Plan(More)
OBJECTIVES To determine the effect of glucocorticoids (GCs) on acute myocardial infarction (MI) risk in patients with RA. METHODS Using administrative health data, we conducted a population-based cohort study of 8384 incident RA cases (1997-2006). Primary exposure was incident GC use. MI events were ascertained using hospitalization and vital statistics(More)
BACKGROUND Since the last decade there has been a gradual change of boundaries of health professions in providing arthritis care. In Canada, some facilities have begun to adopt new arthritis care models, some of which involve physiotherapists (PT) working in extended roles. However, little is known about PTs' interests in these new roles. The primary(More)
BACKGROUND Little is known about the relationships of circulating levels of biomarkers of cartilage degradation with biomechanical outcomes relevant to knee osteoarthritis (OA) or biomarker changes following non-pharmacological interventions. The objectives of this exploratory, pilot study were to: 1) examine relationships between biomarkers of articular(More)
BACKGROUND Modern psychometric methods based on item response theory (IRT) can be used to develop adaptive measures of health-related quality of life (HRQL). Adaptive assessment requires an item bank for each domain of HRQL. The purpose of this study was to develop item banks for five domains of HRQL relevant to arthritis. METHODS About 1,400 items were(More)
BACKGROUND Knee injuries can lead to radiographic osteoarthritis (ROA). Injuries may be "specific" (SI) including ligament or meniscal tears or patellar trauma, or "nonspecific" (NSI). Our objective is to understand the effect of knee NSI on ROA incidence and progression. METHODS 163 people (sample-weighted for population representativeness) aged 40+ with(More)
Aims. The purpose of the study was to develop new self-report instruments to measure the ability to walk, run, and lift objects and describe the distribution of these abilities among older Canadians. Methods. Questions were developed following a focus group. We carried out an online survey among members of the Canadian Association of Retired Persons. The(More)
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