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BACKGROUND Computer simulation models are used increasingly to support public health research and policy, but questions about their quality persist. The purpose of this article is to review the principles and methods for validation of population-based disease simulation models. METHODS We developed a comprehensive framework for validating population-based(More)
BACKGROUND/OBJECTIVE Patients with polymyositis (PM) and dermatomyositis (DM) may have an increased risk of venous thromboembolism (VTE); however, no general population data are available to date. The purpose of this study was to estimate the future risk and time trends of new VTE (deep venous thrombosis (DVT) or pulmonary embolism (PE)) in individuals with(More)
OBJECTIVE Osteoarthritis (OA) is a highly prevalent and often disabling disease. Data on the incidence of OA in the general population are limited. Our objectives were (1) to estimate OA prevalence and incidence rates by age and sex in a geographically defined population of 4 million people [British Columbia (BC), Canada] using an administrative database;(More)
STUDY DESIGN The study used longitudinal data from the first and second cycles (1994-1995 and 1996-1997) of the Canadian National Population Health Survey. OBJECTIVE Our objective was to derive prediction models for back pain in the general male and female household populations. SUMMARY OF BACKGROUND DATA Little is known about the predictors of back(More)
PURPOSE Screening of asymptomatic men with prostate specific antigen (PSA) remains a controversial issue. There is limited evidence that screening is effective in reducing mortality from prostate cancer. In the current study we determined if screening with PSA reduces the risk of metastatic prostate cancer. MATERIALS AND METHODS We conducted a population(More)
OBJECTIVE To compare the incidence and progression of radiographic osteoarthritis (OA) in the knee and hip among African Americans and whites. METHODS Using the joint as the unit of analysis, we analyzed data from the Johnston County Osteoarthritis Project, a population-based prospective cohort study in rural North Carolina. Baseline and followup(More)
STUDY DESIGN We have conducted an outcome instrument validation study. OBJECTIVE Our objective was to develop a computerized adaptive test (CAT) to measure 5 domains of health-related quality of life (HRQL) and assess its feasibility, reliability, validity, and efficiency. SUMMARY OF BACKGROUND DATA Kopec and colleagues have recently developed item(More)
BACKGROUND Osteoarthritis (OA) has a significant impact on individuals' ability to work. Our goal was to investigate the effects of the site of OA (knee, hip, hand, foot, lower back or neck) on employment reduction due to OA (EROA). METHODS AND FINDINGS This study involved a random sample of 6,000 patients with OA selected from the Medical Service Plan(More)
OBJECTIVE The purpose of this study was to determine whether organizational and psychosocial aspects of work experience affect the risk of chronic pain conditions. METHODS We used longitudinal data from the National Population Health Survey in Canada (n = 6571). The data were analyzed using the Cox model. RESULTS Work-related stress was a risk factor(More)
IMPORTANCE Patients with giant cell arteritis (GCA) may have an increased risk of pulmonary embolism (PE), similar to other systemic vasculitidies; however, no relevant population data are available to date. OBJECTIVE To evaluate the future risk and time trends of new venous thromboembolism (VTE) in individuals with incident GCA at the general population(More)