Eric C Maslowski

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Effects of genetic selection for high wheel-running activity (17th generation) and access to running wheels on skeletal muscle glucose uptake were studied in mice with the following treatments for 8 wk: 1) access to unlocked wheels; 2) same as 1, but wheels locked 48 h before glucose uptake measurement; or 3) wheels always locked. Selected mice ran more(More)
BACKGROUND Although neuroimaging techniques have provided insights into the function of brain regions involved in Trigeminal Neuropathic Pain (TNP) in humans, there is little understanding of the molecular mechanisms affected during the course of this disorder. Understanding these processes is crucial to determine the systems involved in the development and(More)
BACKGROUND In a recent study, two-dimensional (2D) network layouts were used to visualize and quantitatively analyze the relationship between chronic renal diseases and regulated genes. The results revealed complex relationships between disease type, gene specificity, and gene regulation type, which led to important insights about the underlying biological(More)
We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ-opioid receptor (μOR)(More)
We evaluated in vivo the l-opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using positron emission tomography with the selective l-opioid receptor (lOR) radiotracer [11C]carfentanil. In the ictal phase, there was lOR activation in the medial prefrontal cortex, which was strongly(More)
A growing body of research, generated primarily from MRI-based studies, shows that migraine appears to occur, and possibly endure, due to the alteration of specific neural processes in the central nervous system. However, information is lacking on the molecular impact of these changes, especially on the endogenous opioid system during migraine headaches,(More)
We evaluated in vivo the μ-opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using Positron Emission Tomography with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. In the ictal phase, there was μOR activation in the medial prefrontal cortex, which was strongly(More)
The Health Mechanics program was created by Dr. Michelle Meade at the University of Michigan, in collaboration with consultants, individuals with spinal cord injury and disease, and health care providers. Support for Health Mechanics was provided by grant #576 from the Paralyzed Veterans of America (PVA) Education Foundation. The information provided in(More)
The Health Mechanics program was created by Dr. Michelle Meade at the University of Michigan, in collaboration with consultants, individuals with spinal cord injury and disease, and health care providers. Support for Health Mechanics was provided by grant #576 from the Paralyzed Veterans of America (PVA) Education Foundation. The information provided in(More)
(1994). Glial hypertrophy is associated with synaptogenesis following motor-skill learning, but not with angiogenesis following exercise. Glia 11, 73-80. (1990). Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. 2001. Open-field behavior of house mice artificially selected for high voluntary(More)
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