Eric C. Frey

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Partial volume (PV) effects degrade the quantitative accuracy of SPECT brain images. In this paper, we extended a PV compensation (PVC) method originally developed for brain PET, the geometric transfer matrix (GTM) method, to brain SPECT using iterative reconstruction-based compensations. In the GTM method a linear transform between the true regional(More)
In this paper, we apply the channelized Hotelling observer (CHO) using a defect detection task to the optimization and evaluation of three-dimensional iterative reconstruction-based compensation methods for myocardial perfusion single-photon emission computed tomography (SPECT). We used a population of 24 mathematical cardiac-torso phantoms that(More)
Receiver operating characteristic (ROC) analysis is well established in the evaluation of systems involving binary classification tasks. However, medical tests often require distinguishing among more than two diagnostic alternatives. The goal of this work was to develop an ROC analysis method for three-class classification tasks. Based on decision theory,(More)
Previously, we have developed a decision model for three-class receiver operating characteristic (ROC) analysis based on decision theory. The proposed decision model maximizes the expected decision utility under the assumption that incorrect decisions have equal utilities under the same hypothesis (equal error utility assumption). This assumption reduced(More)
Previously, we have proposed a method for three-class receiver operating characteristic (ROC) analysis based on decision theory. In this method, the volume under a three-class ROC surface (VUS) serves as a figure-of-merit (FOM) and measures three-class task performance. The proposed three-class ROC analysis method was demonstrated to be optimal under(More)
In simultaneous dual-isotope myocardial perfusion SPECT (MPS) imaging, data are simultaneously acquired to determine the distributions of two radioactive isotopes. The goal of this work was to develop penalized maximum likelihood (PML) algorithms for a novel cross-tracer prior that exploits the fact that the two images reconstructed from simultaneous(More)
Scatter compensation in Tl-201 single photon emission computed tomography (SPECT) presents an interesting challenge because of the multiple emission energies and relatively large proportion of scattered photons. In this paper, we present a simulation study investigating reconstructed image noise levels arising from various implementations of iterative(More)
Estimating the residence times in tumor and normal organs is an essential part of treatment planning for radioimmunotherapy (RIT). This estimation is usually done using a conjugate view whole body scan time series and planar processing. This method has logistical and cost advantages compared to 3-D imaging methods such as Single photon emission computed(More)
The ideal observer (IO) employs complete knowledge of the available data statistics and sets an upper limit on observer performance on a binary classification task. However, the IO test statistic cannot be calculated analytically, except for cases where object statistics are extremely simple. Kupinski have developed a Markov chain Monte Carlo (MCMC) based(More)