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Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor
The glucocorticoid receptor (GR) associates with glucocorticoid response elements (GREs) and regulates selective gene transcription in a cell-specific manner. Native GREs are typically thought to be… Expand
Cell- and gene-specific regulation of primary target genes by the androgen receptor.
- Eric C Bolton, A. So, C. Chaivorapol, C. Haqq, H. Li, K. Yamamoto
- Biology, Medicine
- Genes & development
- 15 August 2007
The androgen receptor (AR) mediates the physiologic and pathophysiologic effects of androgens including sexual differentiation, prostate development, and cancer progression by binding to genomic… Expand
Transcriptional interactions between yeast tRNA genes, flanking genes and Ty elements: a genomic point of view.
Retroelement insertion can alter the expression of nearby genes. The Saccharomyces cerevisiae retrotransposons Ty1-Ty4 are transcribed by RNA polymerase II (pol II) and target their integration… Expand
Inhibition of reverse transcription in vivo by elevated manganese ion concentration.
Mutations in PMR1, a yeast gene encoding a calcium/manganese exporter, dramatically decrease Ty1 retrotransposition. Ty1 cDNA is reduced in pmr1 mutant cells, despite normal levels of Ty1 RNA and… Expand
Androgens and androgen receptor signaling in prostate tumorigenesis.
Androgens and androgen receptor (AR) signaling are necessary for prostate development and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The role of androgens… Expand
Non-competitive androgen receptor inhibition in vitro and in vivo
- J. O. Jones, Eric C Bolton, +5 authors M. Diamond
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 28 April 2009
Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available anti-androgens target only… Expand
Identification and characterization of critical cis-acting sequences within the yeast Ty1 retrotransposon.
The yeast long terminal repeat (LTR) retrotransposon Ty1, like retroviruses, encodes a terminally redundant RNA, which is packaged into virus-like particles (VLPs) and is converted to a DNA copy by… Expand
Mn2+ Suppressor Mutations and Biochemical Communication between Ty1 Reverse Transcriptase and RNase H Domains
ABSTRACT Ty1 reverse transcriptase/RNase H (RT/RH) is exquisitely sensitive to manganese concentrations. Elevated intracellular free Mn2+ inhibits Ty1 retrotransposition and in vitro Ty1… Expand
N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity
BackgroundHomeostatic intrinsic plasticity encompasses the mechanisms by which neurons stabilize their excitability in response to prolonged and destabilizing changes in global activity. However, the… Expand
Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells
The androgen receptor (AR) mediates the developmental, physiologic, and pathologic effects of androgens including 5α-dihydrotestosterone (DHT). However, the mechanisms whereby AR regulates growth… Expand