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Specific recognition between two biological partners is widely exploited in biosensors nowadays. To explore this avenue, a novel biosensor for antithrombin (AT) detection was constructed. Heparin was used as the affinity ligand. A well-known acrylic monomer (butyl methacrylate) was polymerized and grafted onto the heparin polysaccharide by the use of ceric(More)
In this work, we study the electrochemical properties of protein layer grafted on gold electrode for C-reactive protein detection. Two CRP-antibody immobilization methods were used: the first method is based on direct physisorption of CRP-antibody onto the gold surface and the second method is based on oriented CRP-antibody with protein G intermediate(More)
We state sufficient conditions for the existence of positive bounded, almost auto-morphic or almost periodic solutions of the following nonlinear infinite delay integral equation: x(t) = t −∞ a(t, t − s)f (s, x(s)) ds. Then we apply these results to a finite delay integral equation when the delay is time-dependent and for a delay differential equation.
Introduction: Short-term studies (3-6 weeks) in humans have suggested that high-dose benfotiamine (up to 600mg/ day) can improve symptomatic scores in diabetic polyneuropathy. To assess the efficacy of long-term supplementation, we have carried out a 24-month, randomised, double-blind, placebo-controlled study to evaluate whether 300mg/day benfotiamine(More)
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