Eric A. Engleman

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Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication.

David T. Wong, Frank P. Bymaster, Eric A. Engleman
Life sciences
1995

In this review, we describe the evolutionary process involved in the discovery of the selective 5-HT uptake inhibitor, fluoxetine, and summarize some of the large body of scientific research… (More)

Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats.

Zheng-Ming Ding, Zachary A. Rodd, Eric A. Engleman, Jason A. Bailey, Debomoy K. Lahiri, William J H Mcbride
Addiction biology
2013

The present study determined the effects of voluntary ethanol drinking and deprivation on basal extracellular glutamate concentrations and clearance in the mesolimbic system and tested the hypothesis… (More)

Sensitization of ventral tegmental area dopamine neurons to the stimulating effects of ethanol.

Zheng-Ming Ding, Zachary A. Rodd, Eric A. Engleman, William J H Mcbride
Alcoholism, clinical and experimental research
2009

BACKGROUND Previous studies indicated that chronic alcohol drinking increased the sensitivity of the posterior ventral tegmental area (p-VTA) to the reinforcing effects of ethanol. The current study… (More)

Microdialysis of dopamine in the nucleus accumbens of alcohol-preferring (P) rats during anticipation and operant self-administration of ethanol.

Roberto I. Melendez, Zachary A. Rodd-Henricks, Eric A. Engleman, Ting-hao Li, William J H Mcbride, James M Murphy
Alcoholism, clinical and experimental research
2002

BACKGROUND The present study was designed to test directly whether a contextual stimulus for access to ethanol would acquire the ability to enhance locomotor activity and dopamine efflux in the… (More)

Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats.

Richard J. Thielen, Eric A. Engleman, +4 authors William J H Mcbride
The Journal of pharmacology and experimental…
2004

The alcohol deprivation effect is a temporary increase in the intake of, or preference for, ethanol after a period of deprivation that may result from persistent changes in key limbic regions thought… (More)

The stimulating effects of ethanol on ventral tegmental area dopamine neurons projecting to the ventral pallidum and medial prefrontal cortex in female Wistar rats: regional difference and…

Zheng-Ming Ding, Scott M. Oster, +4 authors Zachary A. Rodd
Psychopharmacology
2011

The ventral tegmental area (VTA) mediates the local stimulating effects of ethanol (EtOH) in a region-dependent manner, with EtOH administration in the posterior but not anterior VTA stimulating the… (More)

Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: modeling adolescent and adult binge-like drinking.

Richard L. Bell, Zachary A. Rodd, Eric A. Engleman, Jamie E. Toalston, William J H Mcbride
Alcohol
2014

Binge alcohol drinking continues to be a public health concern among today's youth and young adults. Moreover, an early onset of alcohol use, which usually takes the form of binge drinking, is… (More)

Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell.

Gerald A Deehan, Eric A. Engleman, Zheng-Ming Ding, William J H Mcbride, Zachary A. Rodd
Alcoholism, clinical and experimental research
2013

BACKGROUND Published findings indicate that acetaldehyde (ACD; the first metabolite of ethanol [EtOH]) and salsolinol (SAL; formed through the nonenzymatic condensation of ACD and dopamine [DA]) can… (More)

Targeting glutamate uptake to treat alcohol use disorders

P.S.S. Rao, Richard L. Bell, Eric A. Engleman, Youssef Sari
Front. Neurosci.
2015

Alcoholism is a serious public health concern that is characterized by the development of tolerance to alcohol's effects, increased consumption, loss of control over drinking and the development of… (More)

Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: A microdialysis study

Shafiqur Rahman, Jianhua Zhang, Eric A. Engleman, William A. Corrigall
Neuroscience
2004

There is little evidence to date to indicate if mesoaccumbens dopamine function at the neurochemical level is altered during early abstinence from chronic i.v. nicotine self-administration. Thus, a… (More)

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