Eric A. Bernard

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BACKGROUND The replicative cycle of chikungunya virus (CHIKV), an alphavirus that recently re-emerged in India and in Indian Ocean area, remains mostly unknown. The aim of the present study was to investigate the intracellular trafficking pathway(s) hijacked by CHIKV to enter mammalian cells. METHODOLOGY/PRINCIPAL FINDINGS Entry pathways were investigated(More)
The ultimate stage of the transmission of Dengue Virus (DENV) to man is strongly dependent on crosstalk between the virus and the immune system of its vector Aedes aegypti (Ae. aegypti). Infection of the mosquito's salivary glands by DENV is the final step prior to viral transmission. Therefore, in the present study, we have determined the modulatory(More)
BACKGROUND The machinery of early HIV-1 replication still remains to be elucidated. Recently the viral core was reported to persist in the infected cell cytoplasm as an assembled particle, giving rise to the reverse transcription complex responsible for the synthesis of proviral DNA and its transport to the nucleus. Numerous studies have demonstrated that(More)
The human immunodeficiency virus type 1 (HIV-1) Vpr protein binds to the cellular uracil-DNA glycosylase UNG2 and induces its degradation through the assembly with the DDB1-CUL4 ubiquitin ligase complex. This interaction counteracts the antiviral activity exerted by UNG2 on HIV-1 gene transcription, as previously reported by us. In this work, we show that(More)
Since the end of the Little Ice Age (LIA), Svalbard glaciers have undergone a net retreat in response to changing meteorological conditions. Located between 76°N and 80°N, western Spitsbergen has seen a climatic transition from a glacial to a paraglacial system. On the northern shore of the Brøgger Peninsula (northwest Spitsbergen), the average temperature(More)
Capsid protein (CA) is the major component of the HIV-1 core. Three major phosphorylation sites have been identified at positions S 109 , S 149 and S 178 in amino-acid sequence of CA. Here we investigated the possible consequences of phosphorylation at these sites on CA hexamer formation and core assembly. Using in silico modeling approaches we found that(More)
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