Erhan Kiziltan

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In this study, we demonstrated that sodium selenite with high doses (≥ 10-3 M) were potent in inducing a contracture type effect on heart and smooth muscles. Selenite (Se), at a concentration of 10-3 M, caused a contracture effect in heart preparations. Also, low Se concentrations did not have any significant effect. Although low concentrations of Se (≥(More)
Nerve conduction velocity distribution (CVD) is a very useful tool to examine the state and function of nerves. Only one record of compound action potential (CAP) may be sufficient to determine the CVD if the shape functions of the single fiber action potentials (SFAP) of fibers are known. Otherwise, CAP recordings from different locations are necessary to(More)
The aim of this study was to document the effect of tramadol as an opioid on individual fibers of rat sciatic nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated nerves treated with tramadol from five different concentration levels. Then recorded CAPs and the control group were analyzed by numerical methods(More)
BACKGROUND AND AIM The aim of this randomized double blind placebo controlled study was to investigate the effectiveness and the safety of venlafaxine XR 75 and 150 mg on ongoing pain and on quantitative sensory tests in 60 patients with neuropathic pain for 8 weeks. METHODS Evaluation parameters consisted of ongoing pain intensity (VAS), patient(More)
In order to get early information on the functional state of smaller myelinated fibers this article investigated the applicability of conduction velocity distribution on compound action potential recorded in experimentally demyelinated frog sciatic nerve. Conduction velocity distribution histograms were estimated by using the mathematical model the authors(More)
Finger-tapping test is extensively employed to assess motor asymmetry in brain damaged patients and also to study the relationship between handedness and performance in normal subjects. The aim of this study was to develop a computer based finger-tapping system that could provide quantitative measures of finger-tapping performance. The system is designed to(More)
In this study, the distribution of peroneal-nerve conduction velocity was studied in 17 normal subjects, using the collision method. Paired supramaximal stimuli with predetermined interstimulus intervals (ISI) were applied at distal and proximal points of peroneal nerve and the resultant compound muscle action potentials (CMAPs) were recorded. The change in(More)
Collegenase is widely used in the process of teasing a nerve in order to perform single fiber action potential (SFAP) recordings. In this study, the effects of collagenase on nerve conduction parameters were investigated. To accomplish this, normal compound action potentials (nCAPs) were recorded from isolated frog sciatic nerve at various distances using(More)
Comet assay or single-cell gel electrophoresis is a widely used method for DNA damage assessment. The results of the method can be scored under microscopic examination either with the naked eye or by automated systems. In this study, we present a semi-automatic comet assay analysis tool that was developed in our laboratory. The results obtained with our(More)
In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction(More)