Epari Sridhar

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Spindle cell oncocytoma of the adenohypophysis is a recently described, spindle and granular cell, S-100 protein-positive, GFAP-negative, neuroendocrine marker-negative, mitochondria-rich neoplasm of uncertain histogenesis that can clinically and radiologically mimic pituitary adenoma. We present two cases of this entity to extend understanding of this(More)
Meningiomas (MGs) are frequent tumors of the CNS originating from the meningeal layers of the spinal cord and the brain. In this study, comparative tissue proteomic analysis of low and high grades of MGs was performed by using iTRAQ-based quantitative proteomics in combination with ESI-quadrupole-TOF and Q-Exactive MS, and results were validated by(More)
Gliosarcomas are uncommon variants of glioblastoma bearing the histological hallmark of two distinct tumor components (high grade glial and sarcomatous). They share similarities with glioblastomas as far as clinico-epidemiological and prognostic factors are concerned. They are commonly cortically-surfacing lesions occurring mostly in the supratentorial(More)
Intraoperative imaging is increasingly being used in resection of brain tumors. Navigable three-dimensional (3D)-ultrasound is a novel tool for planning and guiding such resections. We review our experience with this system and analyze our initial results, especially with respect to malignant gliomas. A prospective database for all patients undergoing(More)
BACKGROUND Medulloblastoma has recently been found to consist of 4 molecularly and clinically distinct subgroups: WNT, Sonce hedgehog (SHH), Group 3, and Group 4. Deregulated microRNA expression is known to contribute to pathogenesis and has been shown to have diagnostic and prognostic potential in the classification of various cancers. METHODS Molecular(More)
Central nervous system germ cell tumors (CNS GCTs) are relatively rare neoplasms. Incidence of CNS GCTs in Western literature is low (0.3–0.6 %) as compared to East Asia (3–4 %). No large study is available on CNS GCTs from India. Intracranial GCT cases were retrieved from databases of three tertiary care institutes in India; clinicopathological data was(More)
BACKGROUND The uniqueness of adolescent and young adult (AYA) non-Hodgkin lymphomas (NHL) with respect to biology and treatment have largely remained unanswered due to marked heterogeneity in treatment, paucity of prospective, or retrospective studies and poor representation of AYA in clinical trials. This audit attempts to put forward the(More)
CONTEXT The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This(More)
Primary optic nerve sheath meningiomas (ONM) are rare. Most of these are World Health Organization Grade I meningiomas. Because of the intimate relationship to the optic nerve sheath from which they arise, radical excision is often not feasible. The chordoid variant of meningioma is an infrequent tumor and extremely uncommon among primary ONMs. We report a(More)
Malignant rhabdoid tumor (MRT) most commonly occurs in kidney. In the central nervous system, cerebellum is the most common site of occurrence. CNS rhabdoid tumors typically occur in small children, do not respond favorably to treatment and are usually fatal within 1-year. Here is reported a 4-year-old child who presented with features of raised(More)