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Oxidative stress is one of the causes of cardiomyopathy. In the present study, NecroXs, novel class of mitochondrial ROS/RNS scavengers, were evaluated for cardioprotection in in vitro and in vivo model, and the putative mechanism of the cardioprotection of NecroX-7 was investigated by global gene expression profiling and subsequent biochemical analysis.(More)
The identification and clinical validation of cancer driver genes are essential to accelerate the translational transition of cancer genomics, as well as to find clinically confident targets for the therapeutic intervention of cancers. Here we identified recurrent LMNA-NTRK1 and TPM3-NTRK1 fusions in Korean patients with colon cancer (3 out of 147, 2%)(More)
  • Influ Ant, Jun S, +4 authors Hyun Kang
  • 2010
Downloa kground: Prior studies suggest that obesity is inversely associated with tumor marker concentration ay reduce diagnostic precision. This study was undertaken to evaluate the association between body index (BMI) and serum carcinoembryonic antigen (CEA) concentrations in colorectal cancer patients. thods: We analyzed the association between BMI and(More)
The proteasome is a validated anti-cancer target and various small-molecule inhibitors are currently in clinical development or on the market. However, adverse events and resistance associated with those proteasome inhibitors indicate the need for a new generation of drugs. Therefore, we focused on developing an oral proteasome inhibitor with improved(More)
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