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Contrasting forms of cocaine-evoked plasticity control components of relapse.

• Vincent Jean Pascoli, Jean E. Terrier, Julie Espallergues, Emmanuel Valjent, Eoin C O'Connor, Christian Lüscher
• Nature
• 2014

Nucleus accumbens neurons serve to integrate information from cortical and limbic regions to direct behaviour. Addictive drugs are proposed to hijack this system, enabling drug-associated cues to… (More)

Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning.

• Matthew T. C. Brown, Kelly R. Tan, Eoin C O'Connor, Irina R Nikonenko, Dominique Muller, Christian Lüscher
• Nature
• 2012

The ventral tegmental area (VTA) and nucleus accumbens (NAc) are essential for learning about environmental stimuli associated with motivationally relevant outcomes. The task of signalling such… (More)

Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.

• Martin Novák, Briac Halbout, +9 authors David Engblom
• The Journal of neuroscience : the official…
• 2010

Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental… (More)

Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs.

• Eoin C O'Connor, Sebastiano Bariselli, Camilla Bellone
• The European journal of neuroscience
• 2014

Most of us engage in social interactions on a daily basis and the repertoire of social behaviors we acquire during development and later in life are incredibly varied. However, in many… (More)

Homeostasis Meets Motivation in the Battle to Control Food Intake.

• Carrie R Ferrario, Gwenaël Labouèbe, +4 authors Eoin C O'Connor
• The Journal of neuroscience : the official…
• 2016

Signals of energy homeostasis interact closely with neural circuits of motivation to control food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior seen in eating… (More)

Genome expansion and lineage-specific genetic innovations in the forest pathogenic fungi Armillaria

• György Sipos, Arun N Prasanna, +29 authors László G Nagy
• Nature Ecology & Evolution
• 2017

Armillaria species are both devastating forest pathogens and some of the largest terrestrial organisms on Earth. They forage for hosts and achieve immense colony sizes via rhizomorphs, root-like… (More)

Tramadol acts as a weak reinforcer in the rat self-administration model, consistent with its low abuse liability in humans.

• Eoin C O'Connor, Andy N. Mead
• Pharmacology, biochemistry, and behavior
• 2010

Rodent models of abuse potential are considered to represent a false positive with respect to the low risk of abuse liability associated with the atypical opioid analgesic tramadol. This may reflect… (More)

The mGluR5 Antagonist MTEP Dissociates the Acquisition of Predictive and Incentive Motivational Properties of Reward-Paired Stimuli in Mice

• Eoin C O'Connor, Hans S. Crombag, Andy N. Mead, David N. Stephens
• Neuropsychopharmacology
• 2010

An environmental stimulus paired with reward (a conditioned stimulus; CS) can acquire predictive properties that signal reward availability and may also acquire incentive motivational properties that… (More)

Modeling appetitive Pavlovian-instrumental interactions in mice.

• Eoin C O'Connor, David N. Stephens, Hans S. Crombag
• Current protocols in neuroscience
• 2010

In appetitive Pavlovian associative learning, a stimulus (conditioned stimulus, CS) that has been associated with the delivery of a reinforcing event (unconditioned stimulus, US; e.g., food) can… (More)

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