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The authors studied the efficacy and safety of combined venlafaxine and quetiapine treatment for treatment-resistant depression (TRD) by dividing 95 TRD patients into two treatment groups: a combined venlafaxine (225 mg/day) and quetiapine (400 mg/day) group and a venlafaxine-only (225 mg/day) group for 8 weeks. Efficacy was assessed with the Hamilton(More)
OBJECTIVE To investigate event-related potential in executive function of attention and characteristics of cerebral perfusion by 99mTc-ECD single-photon emission computed tomography (SPECT) in depression patients receiving the Oddball task. METHODS A total of 30 depression patients and 30 normal control subjects were selected to carry out the Oddball(More)
OBJECTIVE To investigate whether personality traits are related to emotional symptoms (mania, hypomania, and depression) in Chinese patients with bipolar disorders. METHODS Patients with bipolar I and II disorders, and healthy volunteers, were assessed using the Chinese Adjective Descriptors of Personality (CADP) questionnaire, Mood Disorder Questionnaire(More)
BACKGROUND Impaired functional connectivity in the default mode network (DMN) is supposedly involved in Alzheimer's disease (AD) progression. The posterior cingulate cortex (PCC) might be an imaging marker for monitoring AD progression. OBJECTIVE To investigate the alterations in the directed functional connectivity between the PCC and whole brain in(More)
Impaired functional connectivity in the Default Mode Network (DMN) may be involved in the progression of Alzheimer's Disease (AD). The Posterior Cingulate Cortex (PCC) is a potential imaging marker for monitoring the progression of AD. Previous studies did not focus on the functional connectivity between the PCC and nodes in regions outside the DMN, but our(More)
As one of the most common mental disorders and the most important precursor of suicide in Alzheimer’s disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying(More)
Many functional magnetic resonance imaging (fMRI) studies have indicated that Granger causality analysis (GCA) is a suitable method for revealing causal effects between brain regions. The purpose of the present study was to identify neuroimaging biomarkers with a high sensitivity to amnestic mild cognitive impairment (aMCI). The resting-state fMRI data of(More)
OBJECTIVE To investigate the clinical therapeutic effects of point-stimulation for obsession. METHODS Sixty cases of obsession were divided into two groups: a control group of 30 cases treated with chlorimipramine (Chl), and a treatment group of 30 cases treated by point-stimulation (PS) plus chlorimipramine (PS+Chl). The therapeutic effects and(More)
BACKGROUND The Illness Attitude Scales (IAS) are considered as one of the most suitable instruments to screen hypochondriasis. PURPOSE Whether it has cross-cultural validity in China remains to be determined. METHODS In Chinese university students (141 women and 141 men), we have administered the IAS, the Zuckerman-Kuhlman Personality Questionnaire(More)
OBJECTIVE To study the clinical effect of acupoint stimulating control (ASC) in treating obsessive compulsive neurosis. METHODS The comparative study was conducted in 65 patients with obsessive compulsive neurosis, they were divided into two groups, the 33 patients in the control group treated with chlorimipramine and the 32 in the tested group treated(More)