Enrique Gordillo

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During aging, there is a decrease in the activity of the 6-phosphogluconate dehydrogenase enzyme in rat liver. The "old" 6-phosphogluconate dehydrogenase enzyme is about 26% less active than the "young" enzyme. In this paper, some biochemical and chemical properties of this enzyme are studied. 2,4,6-Trinitro-benzenesulfonic acid measurements indicate that(More)
The activity of 6-phosphogluconate dehydrogenase (6-PGDH) decreases in aged human erythrocyte populations. The aged enzyme has 11 lysine residues less than the young enzyme, when they are measured with 2,4,6-trinitro-benzenesulfonic acid (TNBS). Treatment of young enzyme with ascorbate for 15 min produces the loss of 8 lysine residues and the diminution of(More)
Rats fed on a low protein diet show an increase in the specific activity of malic enzyme and a concomitant decrease of glutathione concentration. We have studied the effect on malic enzyme activity of supplementing of low protein diet with essential amino acids. Only when methionine was excluded from the diet did the specific activity of malic enzyme(More)
BACKGROUND It is debatable whether surgical repair is routinely indicated in asymptomatic patients with left ventricular pseudoaneurysms. OBJECTIVE To evaluate the long term outcome of patients with pseudoaneurysm after myocardial infarction, focusing on those treated conservatively. METHODS 10 patients with postinfarction left ventricular(More)
OBJECTIVE Several different epidemiological studies have examined the association between the consumption of tea and coronary heart disease. Some, though not all, support the view that tea or flavonoids reduce the risk of cardiovascular heart disease. The aim of this study was to determine the short-to medium-term effect of a green tea extract on vascular(More)
During aging, there is a decrease in the activity of many enzymes. The mechanism causing the loss of activity is still not well understood in most cases. We have studied the decrease in the activities of the malic, 6-phosphogluconate dehydrogenase and superoxide dismutase enzymes. The old malic enzyme is about 36% less active than the young enzyme and the(More)
INTRODUCTION AND OBJECTIVES Exercise-induced left bundle-branch block does not always denote the presence of underlying coronary artery disease. The aim of this study was to analyze the clinical characteristics and evolution of patients with rate-dependent left bundle-branch block. PATIENTS AND METHOD 9,318 consecutive exercise stress studies were(More)
We reviewed the result of treatment of knee osteoarthritis with intraarticular injection of betamethasone derivatives in 100 patients over a 5 year period. Knee involvement was bilateral in 34 of these patients. 1 ml of a mixture of betamethasone dipropionate and betamethasone phosphate was injected intraarticularly in each patient and repeated if needed at(More)
Regional activity of phosphofructokinase enzyme and the amount of the isoenzyme C in 7 areas of young, adult and aged rats brain have been studied. The phosphofructokinase activity in substantia nigra decreased in adult and aged rats, but the maximum decrease was found in the septum of aged rats. There is a regional distribution of the isoenzyme C in the(More)
Lymphoepitheliomas are extremely rare outside the nasopharynx. Extranasopharyngeal lymphoepithellomas may be located in the stomach or digestive tract, and only one single case of esophageal location has been found in our review. In many cases the tumor is related to Epstein-Barr virus infection. We report a case of undifferentiated carcinoma of the distal(More)