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A panel of human-mouse somatic cell hybrids and specific complementary DNA probes were used to map the human tissue plasminogen activator and urokinase genes to human chromosomes 8 and 10, respectively. This result is in contrast to a previous assignment of a plasminogen activator gene to chromosome 6. As neoplastic cells produce high levels of plasminogen(More)
Insulin-dependent diabetes mellitus is widely believed to be an autoimmune disease. Recent onset diabetics show destruction of insulin-secreting pancreatic beta-cells associated with a lymphocytic infiltrate (insulitis), with autoantibodies to beta-cells being found even before the onset of symptoms. Susceptibility to the disease is strongly influenced by(More)
Two new ranking methods for solutions of multi objective optimization problems are proposed in this paper. Theoretical results show that both new ranking methods form a total preorder and are refinements of the pareto dominance relation. These properties make the ranking methods suitable for the selection of a subset of good solutions from a set of(More)
Two methods for ranking of solutions of multi objective optimization problems are proposed in this paper. The methods can be used, e.g. by metaheuristics to select good solutions from a set of non dominated solutions. They are suitable for population based metaheuristics to limit the size of the population. It is shown theoretically that the ranking methods(More)
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