Enrico Mihich

Learn More
Prostaglandins (PGs) have been implicated as possible modulators of the immune response and various inflammatory processes. Various cell components of the immune system are sources of PGs, and mitogen or antigen stimulation of human or murine lymphocytes leads to their enhanced release. They are also released from various human and animal tumours. Thus, as(More)
The capacity of recombinant human interleukin 2 (rl l-l1.2), alone or in combination with recombinant tumor necrosis factor (r-TNFa), to activate murine resident peritoneal macrophages to a tumoricidal state was examined. Resident peritoneal exúdate cells from C57BL/6 mice were cultured for 18 h with activating agents and washed and the ad herent cells(More)
The proliferation kinetics of a fast-growing spontaneous mouse mammary tumor subline (SMT-F) and a slow-growing spontaneous mouse mammary tumor subline (SMT-S) tumor have been determined autoradiographically at 2 different stages of tumor growth. The length of the cell cycle and the growth fraction for SMT-F were 11.2 hr and 0.85, respectively, on Day 14(More)
Experimental animal models Chemopreventive agents Biomarkers Clinical studies Pharmaceutical industry RAPID program Commentary Europe European Science Foundation (ESF) Workshop A B S T R A C T Agents that prevent cancer, delay its onset, or revert premalignant conditions could have dramatic beneficial impacts on human health. Although there is an urgent(More)
The Oslo University Hospital (Norway), the K.G. Jebsen Centre for Breast Cancer Research (Norway), The Radiumhospital Foundation (Norway) and the Fritz-Bender-Foundation (Germany) designed under the conference chairmen (E. Mihich, K.S. Zänker, A.L. Borresen-Dale) and advisory committee (A. Borg, Z. Szallasi, O. Kallioniemi, H.P. Huber) a program at the(More)
Recent advances in the understanding of the molecular phenomena underlying neoplastic development are leading to the recognition of metabolic features characteristic of the cancer cell. It has become possible to visualize the presence of these cells in vivo and to follow their progression toward increasing anaplastic behavior through measurements of(More)
  • 1