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Elite apnea divers have considerably extended the limits of dive depth and duration but the mechanisms allowing humans to tolerate the compression- and decompression-induced changes in alveolar gas partial pressures are still not fully understood. Therefore we measured arterial blood gas tensions and acid-base-status in two elite apnea divers during(More)
OBJECTIVE To test the hypothesis whether pure oxygen ventilation is equally safe and beneficial in fully developed fecal peritonitis-induced septic shock as hyperoxia initiated at the induction of sepsis. DESIGN Prospective, randomized, controlled, experimental study with repeated measures. SETTING Animal research laboratory at a university medical(More)
The field of ventilatory support has changed dramatically with the introduction of improvements in technology and new ventilatory modes. The most recent ventilators are characterized by microprocessor technology, making the interaction between patient and ventilator more sophisticated than ever before. This technology has enabled the development of pressure(More)
  • T. Anhäupl, B. Liebl, +26 authors C. Chopin
  • 1991
l s prospectively staslied 15 septic (P) tifio rxptirecl a basal Ibperrire infusion and the addition of a 2nd CH. Initial and final values for PAJP, I-AP, CI, SR, D02 amyl 402 trure assessed before and after tta second drug had started. 311 15 P rere on Lbomrdne (Dl mean close 8,3 t / g/ndn) infusion. Dobutanitle (Le) sea a:kieci in 7 P (group I nenn dose(More)
PURPOSE To test the hypothesis that a carbamylated EPO-FC fusion protein (cEPO-FC) or recombinant human erythropoietin (rhEPO) would protect against kidney ischemia/reperfusion (I/R) injury in pigs with atherosclerosis. METHODS Anesthetized and mechanically ventilated animals received cEPO-FC (50 μg kg(-1)), rhEPO (5,000 IU kg(-1)), or vehicle (n = 9 per(More)
In awake spontaneously breathing mice, inhaling gaseous hydrogen sulfide (H2S) produced a "suspended animation-like" metabolic status with hypothermia and reduced O2 demand, thus protecting from lethal hypoxia. Murine models may be questioned, however, because due to their large surface area/mass ratio, rodents can rapidly drop their core temperature.(More)
INTRODUCTION Infusing arginine vasopressin (AVP) in vasodilatory shock usually decreases cardiac output and thus systemic oxygen transport. It is still a matter of debate whether this vasoconstriction impedes visceral organ blood flow and thereby causes organ dysfunction and injury. Therefore, we tested the hypothesis whether low-dose AVP is safe with(More)
Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard, inhibition of mitochondrial respiration resulting from blockade of cytochrome c oxidase being the main toxic mechanism. Recently, however, H2S has been recognized as a signaling molecule of the cardiovascular, inflammatory and(More)
Until now, catecholamines were the drugs of choice to treat hypotension during shock states. Catecholamines, however, also have marked metabolic effects, particularly on glucose metabolism, and the degree of this metabolic response is directly related to the beta2-adrenoceptor activity of the individual compound used. Under physiologic conditions, infusing(More)
The pressure-time product (PTP) and work of breathing (W) were measured in 19 intubated patients during weaning from mechanical ventilation after aortocoronary bypass surgery. The patients were supported by two different ventilatory modes: biphasic continuous positive airway pressure (Biphasic CPAP; a ventilatory mode that permits spontaneous breathing at(More)