Enrico Calzia

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Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard, inhibition of mitochondrial respiration resulting from blockade of cytochrome c oxidase being the main toxic mechanism. Recently, however, H2S has been recognized as a signaling molecule of the cardiovascular, inflammatory and(More)
The pressure-time product (PTP) and work of breathing (W) were measured in 19 intubated patients during weaning from mechanical ventilation after aortocoronary bypass surgery. The patients were supported by two different ventilatory modes: biphasic continuous positive airway pressure (Biphasic CPAP; a ventilatory mode that permits spontaneous breathing at(More)
Until now, catecholamines were the drugs of choice to treat hypotension during shock states. Catecholamines, however, also have marked metabolic effects, particularly on glucose metabolism, and the degree of this metabolic response is directly related to the beta2-adrenoceptor activity of the individual compound used. Under physiologic conditions, infusing(More)
Elite apnea divers have considerably extended the limits of dive depth and duration but the mechanisms allowing humans to tolerate the compression- and decompression-induced changes in alveolar gas partial pressures are still not fully understood. Therefore we measured arterial blood gas tensions and acid-base-status in two elite apnea divers during(More)
To compare the lithium-thermal double indicator dilution (Li-thermal), indocyanine green-thermal double indicator dilution (ICG-thermal), single thermal indicator dilution (single-thermal) and gravimetric techniques of extravascular lung water volume (EVLW) measurement in porcine models of acute lung injury. Two animal models designed to invoke a systemic(More)
l s prospectively staslied 15 septic (P) tifio rxptirecl a basal Ibperrire infusion and the addition of a 2nd CH. Initial and final values for PAJP, I-AP, CI, SR, D02 amyl 402 trure assessed before and after tta second drug had started. 311 15 P rere on Lbomrdne (Dl mean close 8,3 t / g/ndn) infusion. Dobutanitle (Le) sea a:kieci in 7 P (group I nenn dose(More)
Objective: To evaluate the function of four currently available, not specifically modified time-cycled ICU ventilators (EVITA 4, Oxylog 2000 HBO and Microvent from Drägerwerk, Germany and Servo 900C, Siemens-Elema, Sweden) under hyperbaric conditions using volume-controlled ventilation (VCV) and, if available, pressure-controlled ventilation (PCV).¶Design:(More)
The field of ventilatory support has changed dramatically with the introduction of improvements in technology and new ventilatory modes. The most recent ventilators are characterized by microprocessor technology, making the interaction between patient and ventilator more sophisticated than ever before. This technology has enabled the development of pressure(More)
The current practice of mechanical ventilation comprises the use of the least inspiratory O2 fraction associated with an arterial O2 tension of 55 to 80 mm Hg or an arterial hemoglobin O2 saturation of 88% to 95%. Early goal-directed therapy for septic shock, however, attempts to balance O2 delivery and demand by optimizing cardiac function and hemoglobin(More)
OBJECTIVE To test the hypothesis whether pure oxygen ventilation is equally safe and beneficial in fully developed fecal peritonitis-induced septic shock as hyperoxia initiated at the induction of sepsis. DESIGN Prospective, randomized, controlled, experimental study with repeated measures. SETTING Animal research laboratory at a university medical(More)