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STUDY DESIGN Case report. OBJECTIVE To report an uncommon case of cerebral hemorrhage due to autonomic dysreflexia (AD) in a spinal cord injury (SCI) patient. SETTING Institut Guttmann, Neurorehabilitation Hospital in Barcelona, Spain. CASE REPORT An SCI patient developed AD due to urinary tract infection after surgery for a pressure sore. The(More)
Spinal cord injury (SCI) has been associated with a marked increase in bone loss and bone remodeling, especially short-term after injury. The absence of mechanical load, mediated by osteocyte mechanosensory function, seems to be a causative factor related to bone loss in this condition. However, the pathogenesis and clinical management of this process(More)
OBJECTIVE To analyse the incidence and factors related to the development and clinical evolution of fractures in patients with traumatic spinal cord injury. DESIGN A retrospective 10-year follow-up study. SETTING Neurorehabilitation centre. SUBJECTS Sixty-three patients (50M/13F) with a mean age of 36 ± 20 years with recent traumatic spinal cord(More)
OBJECTIVE Plastic changes in the human central nervous system can occur at multiple levels, including circuits rostral to the lesion level in spinal cord injury (SCI). GABA is the most important inhibitory neurotransmitter in the brain. The authors hypothesized that one of the consequences of plasticity in SCI patients could be enhancement of brainstem(More)
STUDY DESIGN Case report. OBJECTIVES A case report of tolerance to intrathecal baclofen therapy (ITB) treated with intrathecal morphine ('baclofen holiday'). SETTING Institut Guttmann, Neurorehabilitation Hospital of Barcelona, Spain. CASE REPORT A 30-year-old female patient is described with incomplete paraplegia below T6 on the left side and below(More)
Osteoporosis is a frequent complication related to spinal cord injury (SCI), and data on osteoporosis treatment after SCI is scarce. Treatment with denosumab increases lumbar and femoral BMD and decreases bone turnover markers in individuals with recent SCI. This drug may be a promising therapeutic option in SCI-related osteoporosis. Osteoporosis(More)
Reorganization of the central nervous system following spinal cord injury (SCI) involves changes not only at the cortical level, but also at the level of the brainstem. To further understand changes in excitatory and inhibitory brainstem interneuronal circuits following SCI, we studied recovery curves of the blink reflex (BR) to paired suprathreshold(More)
Spinal cord injury (SCI) has been associated with a marked bone loss after injury and a consequent increased risk of osteoporosis. The evaluation of bone mineral density shortly after SCI is a simple and effective method for predicting the development of osteoporosis during the first year after SCI. Spinal cord injury (SCI) has been associated with a marked(More)
BACKGROUND AND OBJECTIVES Somatic antinociceptive effects of baclofen have been demonstrated in animal models. We hypothesized that if enhanced thermal or pain sensitivity is produced by loss of gamma-aminobutyric acid (GABA)-ergic tone in the central nervous system, spinal administration of GABA agonists might be predicted to be effective in thermal and/or(More)
BACKGROUND No studies have examined the association between RLS and the sequelae of poliomyelitis (PM). We studied the frequency and severity of RLS in a group of consecutive patients with the sequelae of poliomyelitis (PM) and the effect of treatment with dopaminergic drugs. METHODS A diagnosis of RLS was made according to the criteria of the(More)