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PURPOSE To investigate the potential role of caspase-3 in blue light-induced apoptosis in photoreceptor cells. METHODS Cyclic light-raised Sprague-Dawley rats were exposed to 400 to 480 nm light for 6 hours at an irradiance of 0.64 W/m(2). The rats were then kept in darkness for recovery and killed at scheduled time points from 0 hours up to 24 hours(More)
PURPOSE To investigate the effect of different levels of visual field defect in glaucoma on utilities and to test if utilities could be assessed using a general questionnaire such as the EQ-5D. METHODS A cross-sectional study in 199 patients with ocular hypertension or open-angle glaucoma grouped into 5 severity stages according to visual field defects(More)
BACKGROUND AND OBJECTIVE The aim of the present study was to compare intraocular pressure (IOP) reduction and inflammation after selective laser trabeculoplasty (SLT) treatment in patients suffering from primary open angle (POAG) vs pseudoexfoliative (PXFG) glaucoma. STUDY DESIGN/PATIENTS AND METHODS Sixty patients (60 eyes) participated in the study.(More)
PURPOSE To compare two regimens of SLT, ie, SLT with 25 laser spots on 90 degrees of trabecular meshwork and SLT with 50 laser spots on 180 degrees of trabecular meshwork in patients with open-angle glaucoma. PATIENTS AND METHODS In a prospective clinical study, the authors compared pressure-lowering effect of SLT in 2 groups of patients; 1 group (32(More)
PURPOSE To assess resource utilization and costs associated with glaucoma management in France and Sweden. METHODS A total of 267 patient records (121 in France, 146 in Sweden) with diagnoses of primary open-angle glaucoma (POAG) and ocular hypertension (OH), treated medically, were reviewed for a 2-year period (beginning during 1997-99) for relevant(More)
PURPOSE Glaucoma is a progressive optic neuropathy that may lead to blindness. Reducing intraocular pressure (IOP) is the only known treatment to slow progression in glaucoma. IOP can be reduced by pharmaceutical treatment, laser and surgery. The aim of the present study was to assess predictive factors of success after selective laser trabeculoplasty (SLT)(More)
PURPOSE To study the tolerability of the ICare rebound tonometer (RBT) and to establish reference values of the intraocular pressure (IOP) in healthy infants. PARTICIPANTS AND METHODS Forty-six children were recruited. In 6 infants aged 3 to 18 months, it was not possible to conduct the examination. Five children refused all cooperation. In 1 child, only(More)
PURPOSE The purpose of this study was to investigate the tolerability and intraocular pressure (IOP) reducing effect of the first preservative-free prostaglandin tafluprost (Taflotan) in patients exhibiting ocular surface side-effects during latanoprost (Xalatan) treatment. METHODS A total of 158 patients were enrolled in this open-label multicentre(More)
  • E Chen
  • 1993
The activity of cytochrome oxidase, outer nuclear layer thickness, and edema were quantitatively evaluated in the blue-light exposed rat retina. Dark-adapted or cyclic-light reared rats were exposed to blue light with a retinal dose of 380 kJ/m2. Immediately, 1, 2, and 3 day(s) after exposure, the retinas of six rats from each adaptation group were(More)
BACKGROUND Blue-light exposure inhibits cytochrome oxidase and may therefore inhibit retinal metabolism. The reduced metabolism decreases the extrusion of calcium from the photoreceptor cell. Overload of calcium is proposed as one of the factors that lead to photoreceptor degeneration after light exposure. The light-induced photoreceptor degeneration can be(More)