Enke Mählmann

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Motile forces in muscle are generated by the so-called "power stroke," a series of structural changes in the actomyosin cross-bridge driven by hydrolysis of ATP. The initiation of this power stroke is closely related to phosphate release after ATP cleavage and to the change of the myosin head from weak, nonstereospecific actin attachment to strong,(More)
Force generation in striated muscle is based on a cyclic interaction of myosin heads (cross-bridges) with the thin filaments. During each cross-bridge cycle MgATP is hydrolyzed. The force generating steps are associated with Pi and ADP release. Active cycling of the cross-bridges involves alternation between two distinctly different groups of acto-myosin(More)
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