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Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B.
It is reported that didemnin B, a tunicate-derived depsipeptide, has been isolated from a culturable bacterium, Tistrella mobilis YIT 12409. Expand
Konamycins A and B and Rubromycins CA1 and CA2, Aromatic Polyketides from the Tunicate-Derived Streptomyces hyaluromycini MB-PO13T.
Four new aromatic polyketides were isolated from the culture extract of the tunicate-derived Streptomyces hyaluromycini MB-PO13T and 2 showed radical scavenging activity in DPPH and superoxide quenching assays, and 3 and 4 displayed antimicrobial activity against Gram-positive bacteria. Expand
Hyaluromycin, a New Hyaluronidase Inhibitor of Polyketide Origin from Marine Streptomyces sp.
Hyaluromycin (1), a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived Streptomyces sp. as a HAase inhibitor on the basis of HAase activityExpand
Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation
It is demonstrated that hyaluromycin inhibits proliferation and migration of PDAC cells and is a promising new drug against this highly aggressive neoplasm. Expand
Labrenzbactin from a coral-associated bacterium Labrenzia sp.
A new catecholate-containing siderophore, labrenzbactin, was isolated from the fermentation broth of a coral-associated bacterium and showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 and cytotoxicity against P388 murine leukemia cells. Expand
Ktedonoketone and 2’-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi
A thermophilic bacterium Thermosporothrix hazakensis NBRC 105916 which belongs to the class Ktedonobacteria was investigated to explore its biosynthetic potential of secondary metabolites. UV-guidedExpand
Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived Streptomyces sp.
Two bicyclic peptides, nyuzenamides A and B, were discovered from Streptomyces isolated from suspended matter in deep sea water collected in the Sea of Japan and displayed antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells. Expand
Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp
Activity-guided purification led to the isolation of a new aromatic polyketide, akazamicin, along with two known compounds, actinofuranone C and N-formylanthranilic acid, which displayed cytotoxicity against murine B16 melanoma cell line. Expand
Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1
Results strongly suggest that isomethoxyneihumicin and 3 exhibit cytotoxicity against Jurkat cells by inhibiting the cell cycle at the G2/M phase. Expand
Bulbimidazoles A-C, Antimicrobial and Cytotoxic Alkanoyl Imidazoles from a Marine Gammaproteobacterium Microbulbifer Species.
Three new alkanoyl imidazoles, designated bulbimidazoles A-C (1-3), were found from the culture extract of the gammaproteobacterium Microbulbifer sp. DC3-6 isolated from a stony coral of the genusExpand