Learn More
Current therapies to treat gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), and other acid-related diseases either prevent stimulation of the parietal cell (H2 receptor antagonists, H2RAs) or inhibit gastric H+,K+-ATPase (e.g., proton pump inhibitors, PPIs). Of the 2 approaches, the inhibition of the final step in acid production by PPIs(More)
In vivo studies were performed on 28 dogs to evaluate the usefulness of transmission computed tomography (CT) in the detection and quantitation of experimentally induced myocardial infarction. Intravenously administered contrast material was required to define the internal structure of the heart and to differentiate normal from infarcted tissue. Transmural(More)
Several animal experimental studies have shown that the enhanced CT gives the direct evidence of acute myocardial infarction characterized by an initial filling defect and late enhancement in the site of the damaged myocardium. Therefore, we studied experimentally and clinically the diagnostic value of these CT findings in detecting and quantitating recent(More)
To evaluate the applicability of two-dimensional echocardiography to left ventricular volume determination, 30 consecutive patients undergoing biplane left ventricular cineangiography were studied with a wide-angle (84 degrees), phased-array, two-dimensional echocardiographic system. Two echographic projections were used to obtain paired, biplane,(More)
Twenty-three coronary bypass graft patients were evaluated by a contrast-enhanced computed tomography (CT) technique to determine graft patency. Four to six 4.8-second sequenced scans with a 1-second interscan interval were obtained in each patient during the hand injection of 25-30 ml of contrast medium in a peripheral vein. Patency of grafts was(More)
Pressure-flow studies in man during atrial fibrillation.ment of pulsed Doppler echocardiography in the evaluation of aortic valve disease by the development of computerized spectral frequency analysis. An ultrasound system for combined cardiac imaging and Doppler blood flow measurement in man. SUMMARY Left ventricular volumes and ejection fraction were(More)
In the present paper, a collection of experimental data is presented describing the pharmacological profile of omeprazole mainly in dogs and rats. Omeprazole potently inhibited gastric acid secretion in different experimental models. In the dog, for instance, omeprazole was 2-7 times more potent than cimetidine, depending on the route of administration, and(More)