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Determining the functional conformation of a protein from its amino acid sequence remains a central problem in computational biology. In this paper, we establish the mathematical optimal model of protein folding problem (PFP) on two-dimensional space based on the minimal energy principle. A novel hybrid of elastic net algorithm and local search method(More)
One of the most prominent problems in computational biology is to predict the natural conformation of a protein from its amino acid sequence. This paper focuses on the three-dimensional hydrophobic-polar (HP) lattice model of this problem. The modified elastic net (EN) algorithm is applied to solve this nonlinear programming hard problem. The lattice(More)
The prediction of protein conformation from its amino-acid sequence is one of the most prominent problems in computational biology. But it is NP-hard. Here, we focus on an abstraction widely studied of this problem, the two-dimensional hydrophobic-polar protein folding problem (2D HP PFP). Mathematical optimal model of free energy of protein is established.(More)
In this paper, we propose a hybrid nonlinear dynamical system to describe the concentration changes of extracellular and intracellular substances of glycerol bioconversion to 1,3propanedol (1,3-PD) in microbial continuous cultures. It is proved that the solution to the system exists and is continuous with respect to kinetic parameters. Subsequently, a novel(More)
This paper focuses on the improvement of the concentration and productivity of 1,3propanediol from continuous fermentation of glycerol by Klebsiella pneumoniae. A nonlinear steady-state optimization model is presented according to engineering background. A new linear approximating method has been developed in view of the feature of the optimization model.(More)
OBJECTIVE To study the effects of different dose of hydrocortisone (HC) on myocardial function in early stage of sepsis in rabbits. METHODS Twenty-four male rabbits were randomly divided into three groups: model group (n=8), HC low dosage group (10 mg/kg, n=8), HC high dosage group (100 mg/kg, n=8). The model was reproduced by cecal ligation and puncture(More)
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