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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

• David L. Boone, Emre E. Turer, +10 authors Averil Ma
• Nature Immunology
• 2004

A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)–induced signals. We show here that mice doubly deficient in either A20 and TNF or A20 and TNF receptor 1… (More)

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.

• Osamu Hitotsumatsu, Regina-Celeste Ahmad, +9 authors Averil Ma
• Immunity
• 2008

Muramyl dipeptide (MDP), a product of bacterial cell-wall peptidoglycan, activates innate immune cells by stimulating nucleotide-binding oligomerization domain containing 2 (NOD2) -dependent… (More)

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

• Emre E. Turer, Rita Morais Tavares, +6 authors Averil Ma
• The Journal of experimental medicine
• 2008

Toll-like receptors (TLRs) on host cells are chronically engaged by microbial ligands during homeostatic conditions. These signals do not cause inflammatory immune responses in unperturbed mice, even… (More)

Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.

• Timothy T Lu, Michio Onizawa, +10 authors Averil Ma
• Immunity
• 2013

A20 is an anti-inflammatory protein linked to multiple human autoimmune diseases and lymphomas. A20 possesses a deubiquitinating motif and a zinc finger, ZF4, that binds ubiquitin and supports its E3… (More)

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

• Shigeru Oshima, Emre E. Turer, +9 authors Averil Ma
• Nature
• 2009

Proteins that directly regulate tumour necrosis factor receptor (TNFR) signalling have critical roles in regulating cellular activation and survival. ABIN-1 (A20 binding and inhibitor of NF-κB) is a… (More)

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

• Rita Morais Tavares, Emre E. Turer, +8 authors Averil Ma
• Immunity
• 2010

A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against tumor necrosis factor (TNF)-induced programmed cell death. Given recent data linking A20 (TNFAIP3) with… (More)

Dendritic cell expression of A20 preserves immune homeostasis and prevents colitis and spondyloarthritis

• Gianna Elena Hammer, Emre E. Turer, +12 authors Averil Ma
• Nature Immunology
• 2011

Dendritic cells (DCs), which are known to support immune activation during infection, may also regulate immune homeostasis in resting animals. Here we show that mice lacking the ubiquitin-editing… (More)

Homeostatic MyD 88-dependent signals cause lethal infl ammation in the absence of A 20

• Emre E. Turer, Rita Morais Tavares, +6 authors Averil Ma
• 2008

JEM © The Rockefeller University Press $30.00 Vol. 205, No. 2, February 18, 2008 451-464 www.jem.org/cgi/doi/ 451 10.1084/jem.20071108 Higher eukaryotes are colonized by microbial organisms,… (More)

M1677a The Ubiquitin-Editing Enzyme A20 Restricts TCR Induced NFkB and T Cell Activation

• Shigeru Oshima, Rita Morais Tavares, Emre E. Turer, Regina-Celeste Ahmad, Averil Ma
• 2009

Corrigendum: The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

• David L. Boone, Emre E. Turer, +10 authors Averil Ma
• Nature Immunology
• 2005

VOLUME 6 NUMBER 1 JANUARY 2005 NATURE IMMUNOLOGY Erratum: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice Stacey R Dillon, Cindy Sprecher, Angela Hammond, Janine… (More)

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