Emmanuel Zachariah

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Ayyappan K. Rajasekaran5
Jason J. Christiansen5
Elaine M. Langenfeld4
Robert S. Dipaola3
John E. Langenfeld3
2Wen Yue
2Robert S. DiPaola
2Qing Xu
2Xiang-Lin Tan
2John E. Langenfeld

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Publication Year

2008
2016

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Co-author

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Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin
Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inhibitor of differentiation protein/DNA binding proteins (Id1-3). Inhibition of BMP signaling decreases growth and induces cell death of lung cancer… (More)
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy
Metformin and aspirin have been studied extensively as cancer preventative and therapeutic agents. However, the underlying molecular mechanisms for the inhibitory effects of pancreatic cancer development remain undefined. To gain further insight into their biological function in pancreatic cancer, we conducted a transcriptomic analysis using RNA sequencing… (More)
Transforming Growth Factor- Signaling Strength Determines Target Gene Expression Profile in Human Keratinocytes
Transforming Growth Factor-(TGF) maintains keratinocyte homeostasis, and induces epithelial-to-mesenchymal transition (EMT) in response to tissue injury. To investigate how these two TGF responses might become uncoupled during malignant transformation, we examined the TGF-regulated gene expression programs and cellular responses in human keratinocytes as a… (More)
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