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Transforming Growth Factor-Signaling Strength Determines Target Gene Expression Profile in Human Keratinocytes

• Aparna Kareddula, Emmanuel Zachariah, Daniel A. Notterman, Michael Reiss
• 2008

Transforming Growth Factor(TGF ) maintains keratinocyte homeostasis, and induces epithelial-tomesenchymal transition (EMT) in response to tissue injury. To investigate how these two TGF responses… (More)

High incidence of LRAT promoter hypermethylation in colorectal cancer correlates with tumor stage.

• Yu-Wei Cheng, Hanna Pincas, +5 authors Francis Barany
• Medical oncology
• 2014

Lecithin:retinol acyltransferase (LRAT) is a major enzyme involved in vitamin A/retinol metabolism, which regulates various physiological processes like cell proliferation and differentiation. LRAT… (More)

Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy

• Wen Yue, Tao Wang, +5 authors Xiang-Lin Tan
• Scientific reports
• 2015

Metformin and aspirin have been studied extensively as cancer preventative and therapeutic agents. However, the underlying molecular mechanisms for the inhibitory effects of pancreatic cancer… (More)

Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin

• Elaine M Langenfeld, Malik F Deen, Emmanuel Zachariah, John E. Langenfeld
• Molecular Cancer
• 2013

Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription… (More)

GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1.

• Yu xiang Wen, Sarah F. Giardina, +10 authors Daniel A. Notterman
• Clinical cancer research : an official journal of…
• 2006

PURPOSE The growth-related oncogene alpha (GROalpha) is a secreted interleukin-like molecule that interacts with the CXCR2 G-protein-coupled receptor. We found that the mRNA and protein products of… (More)

Therapeutic Connection Between Black Tea Theaflavins and Their Benzotropolone Core Structure

• Alexander Gosslau, Shiming Li, Emmanuel Zachariah, Chitang Ho
• Current Pharmacology Reports
• 2018

The discrepancy between strong bioactivity and health promoting effects of black tea polyphenols despite their poor bioavailability is an elusive phenomenon in tea research. We discuss the theaflavin… (More)

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