Emmanuel Zachariah

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Ayyappan K Rajasekaran5
Jason J Christiansen5
Robert S. DiPaola4
Elaine M Langenfeld4
John E. Langenfeld3
3Francis Barany
3Daniel A Notterman
2Sarah F Giardina
2Manny D Bacolod
2Philip B Paty

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1983
2016
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GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1.
PURPOSE The growth-related oncogene alpha (GROalpha) is a secreted interleukin-like molecule that interacts with the CXCR2 G-protein-coupled receptor. We found that the mRNA and protein products of GROalpha are more highly expressed in neoplastic than normal colon epithelium, and we studied potential mechanisms by which GROalpha may contribute to tumor… (More)
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy
Metformin and aspirin have been studied extensively as cancer preventative and therapeutic agents. However, the underlying molecular mechanisms for the inhibitory effects of pancreatic cancer development remain undefined. To gain further insight into their biological function in pancreatic cancer, we conducted a transcriptomic analysis using RNA sequencing… (More)
Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin
Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inhibitor of differentiation protein/DNA binding proteins (Id1-3). Inhibition of BMP signaling decreases growth and induces cell death of lung cancer… (More)
High incidence of LRAT promoter hypermethylation in colorectal cancer correlates with tumor stage.
Lecithin:retinol acyltransferase (LRAT) is a major enzyme involved in vitamin A/retinol metabolism, which regulates various physiological processes like cell proliferation and differentiation. LRAT expression is reduced in numerous cancers, yet the underlying mechanisms have remained undefined. We hypothesized that methylation silencing may contribute to… (More)
Transforming Growth Factor- Signaling Strength Determines Target Gene Expression Profile in Human Keratinocytes
Transforming Growth Factor-(TGF) maintains keratinocyte homeostasis, and induces epithelial-to-mesenchymal transition (EMT) in response to tissue injury. To investigate how these two TGF responses might become uncoupled during malignant transformation, we examined the TGF-regulated gene expression programs and cellular responses in human keratinocytes as a… (More)
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