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  • Emanuela Santini, Emmanuel Valjent, +6 authors Gilberto Fisone
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2007 (First Publication: 27 June 2007)
  • The molecular basis of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID), one of the major hindrances in the current therapy for Parkinson's disease, is still unclear. We show thatExpand
  • Jesus Bertran-Gonzalez, Clémentine Bosch, +4 authors Jean-Antoine Girault
  • Medicine, Biology
  • The Journal of Neuroscience
  • 2008 (First Publication: 28 May 2008)
  • Psychostimulants and other drugs of abuse activate extracellular signal-regulated kinase (ERK) in the striatum, through combined stimulation of dopamine D1 receptors (D1Rs) and glutamate NMDAExpand
  • E. Valjent, V. Pascoli, +10 authors J. Girault
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 11 January 2005)
  • Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the nucleus accumbens, where they likely alter the plasticity of corticostriatal glutamatergic transmission.Expand
  • Karen Brami-Cherrier, Emmanuel Valjent, +6 authors Jocelyne Caboche
  • Medicine, Biology
  • The Journal of Neuroscience
  • 2005 (First Publication: 7 December 2005)
  • Although the induction of persistent behavioral alterations by drugs of abuse requires the regulation of gene transcription, the precise intracellular signaling pathways that are involved remainExpand