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Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
Mucosal-associated invariant T (MAIT) cells are very abundant in humans and have antimicrobial specificity, but their functions remain unclear. MAIT cells are CD161(hi)IL-18Rα(+) and eitherExpand
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Antimicrobial activity of mucosal-associated invariant T cells
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) α-chain and restriction by theExpand
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The transcription factor PLZF directs the effector program of the NKT cell lineage.
The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family ofExpand
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MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells
Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented byExpand
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Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.
BACKGROUND Primary immunodeficiencies are a rare group of inborn diseases characterized by a broad clinical and genetic heterogeneity. Substantial advances in the identification of the underlyingExpand
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Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans.
Collective epithelial cell migration requires the maintenance of cell-cell junctions while enabling the generation of actin-rich protrusions at the leading edge of migrating cells. Ventral enclosureExpand
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Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes
Antagonism between the GTPases Rac1 and RhoA controls different morphogenetic processes during embryonic development. Martin et al. use quantitative imaging analyses to demonstrate thatExpand
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Corrigendum: Antimicrobial activity of mucosal-associated invariant T cells
Nat. Immunol. 11, 701–708 (2010); published online 27 June 2010; corrected after print 13 August 2010 In the version of this article initially published, the author Shouxiong Huang (Department ofExpand
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Novel Metrics to Characterize Embryonic Elongation of the Nematode Caenorhabditis elegans.
Dissecting the signaling pathways that control the alteration of morphogenic processes during embryonic development requires robust and sensitive metrics. Embryonic elongation of the nematodeExpand
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Super-resolved live-cell imaging using Random Illumination Microscopy
Super-resolution fluorescence microscopy has been instrumental to progress in biology. Yet, the photo-induced toxicity, the loss of resolution into scattering samples or the complexity of theExpand
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