Emmanuel Lazaridis

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We present code for the calculation and evaluation of continuously monitored stopping boundaries for use in one-arm and two-arm clinical trials. These designs were first developed for one-arm trials by Thall, Simon and Estey (TSE) (P.F. Thall, R. Simon, E.H. Estey, Bayesian sequential monitoring designs for single-arm clinical trials with multiple outcomes,(More)
This paper presents a non-linear analog synthesis path towards the modeling and full implementation of the Hodgkin-Huxley neuronal dynamics in silicon. The proposed circuits have been realized in weak-inversion CMOS technology and take advantage of both log-domain and translinear transistor-level techniques.
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