Emmanuel Ampofo

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Protein kinase CK2, a ubiquitous serine/threonine kinase in control of a variety of crucial cellular functions, is composed of catalytic α- and α′-subunits and non-catalytic β-subunits which form holoenzymes such as CK2(αβ)2, CK2αα′β2, or CK2(α′β)2. In addition, there is ample evidence for the occurrence of the individual subunits beside the holoenzyme.(More)
BACKGROUND The marine-derived kinase inhibitor fascaplysin down-regulates the PI3K pathway in cancer cells. Since this pathway also plays an essential role in platelet signaling, we herein investigated the effect of fascaplysin on thrombosis. METHODS Fascaplysin effects on platelet activation, platelet aggregation and platelet-leukocyte aggregates (PLA)(More)
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