Emmanouil Froudarakis

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Neural responses are modulated by brain state, which varies with arousal, attention, and behavior. In mice, running and whisking desynchronize the cortex and enhance sensory responses, but the quiescent periods between bouts of exploratory behaviors have not been well studied. We found that these periods of "quiet wakefulness" were characterized by state(More)
Neural codes are believed to have adapted to the statistical properties of the natural environment. However, the principles that govern the organization of ensemble activity in the visual cortex during natural visual input are unknown. We recorded populations of up to 500 neurons in the mouse primary visual cortex and characterized the structure of their(More)
Ambitious projects aim to record the activity of ever larger and denser neuronal populations in vivo. Correlations in neural activity measured in such recordings can reveal important aspects of neural circuit organization. However, estimating and interpreting large correlation matrices is statistically challenging. Estimation can be improved by(More)
A fundamental challenge in calcium imaging has been to infer spike rates of neurons from the measured noisy fluorescence traces. We systematically evaluate different spike inference algorithms on a large benchmark dataset (>100,000 spikes) recorded from varying neural tissue (V1 and retina) using different calcium indicators (OGB-1 and GCaMP6). In addition,(More)
1 Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany 2 Institute of Theoretical Physics, University of Tübingen, Tübingen, Germany 3 Bernstein Center for Computational Neuroscience, University of Tübingen, Tübingen, Germany 4 Department of Neuroscience, Baylor College of Medicine, Houston, USA 5 Institute for Ophthalmic Research,(More)
Great progress has been made toward understanding the properties of single neurons, yet the principles underlying interactions between neurons remain poorly understood. Given that connectivity in the neocortex is locally dense through both horizontal and vertical connections, it is of particular importance to characterize the activity structure of local(More)
Sensory maps are created by networks of neuronal responses that vary with their anatomical position, such that representations of the external world are systematically and topographically organized in the brain. Current understanding from studying excitatory maps is that maps are sculpted and refined throughout development and/or through sensory experience.(More)
The critique of Barth et al centers on three points: (i) the completeness of our study is overstated; (ii) the connectivity matrix we describe is biased by technical limitations of our brain-slicing and multipatching methods; and (iii) our cell classification scheme is arbitrary and we have simply renamed previously identified interneuron types. We address(More)
1 Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany 2 Institute of Theoretical Physics, University of Tübingen, Tübingen, Germany 3 Bernstein Center for Computational Neuroscience, University of Tübingen, Tübingen, Germany 4 Department of Neuroscience, Baylor College of Medicine, Houston, USA 5 Institute for Ophthalmic Research,(More)
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