Emma Svensk

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C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty(More)
In spite of the worldwide impact of diabetes on human health, the mechanisms behind glucose toxicity remain elusive. Here we show that C. elegans mutants lacking paqr-2, the worm homolog of the adiponectin receptors AdipoR1/2, or its newly identified functional partner iglr-2, are glucose intolerant and die in the presence of as little as 20 mM glucose.(More)
PAQR-2 is a C. elegans homolog of the mammalian adiponectin receptors. We have recently shown that PAQR-2 is essential for the ability of C. elegans to grow at its lower temperature range, i.e., 15 °C, and that the likely role of PAQR-2 during cold adaptation is to regulate membrane fluidity by promoting fatty acid desaturation. Here we present a summary of(More)
Some ORF names, lengths and mutations in Table 1 are incorrect. Specifically, the ORF names and ORF lengths listed for the paqr-2(et36) and paqr-2(et35) alleles, and the ORF names and mutations listed for the iglr-2(et34), iglr-2(et37) and iglr-2(et38) alleles. The shift by one amino acid position in the mutation column also applies to the iglr-2mutations(More)
The properties of cellular membranes are critical for most cellular functions and are influenced by several parameters including phospholipid composition, integral and peripheral membrane proteins, and environmental conditions such as temperature. We previously showed that the C. elegans paqr-2 and iglr-2 mutants have a defect in membrane homeostasis and(More)
Dietary fatty acids can be incorporated directly into phospholipids. This poses a specific challenge to cellular membranes since their composition, hence properties, could greatly vary with different diets. That vast variations in diets are tolerated therefore implies the existence of regulatory mechanisms that monitor and regulate membrane compositions.(More)
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