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RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.
We have used a c-Src-GFP fusion protein to address the spatial control of Src activation and the nature of Src-associated intracellular structures during stimulus-induced transit to the membrane. SrcExpand
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A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity
A fundamental question in cell biology concerns how cells respond to their environment by polarizing after sensing directional cues. This requires the differential localization of protein complexesExpand
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Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors
The non‐receptor tyrosine kinase Src is recruited to activated fibroblast growth factor receptor (FGFR) complexes through the adaptor protein factor receptor substrate 2 (FRS2). Here, we show thatExpand
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Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling
Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK pathway is severely perturbed. Depletion of FAK, detachment of FAK-proficient cells or expression ofExpand
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Endosomal trafficking of Src tyrosine kinase.
Endosomal trafficking is an essential cellular process involved in the transport of proteins such as integrins, hormone receptors, growth factor receptors, receptor tyrosine kinases, and lipids (e.g.Expand
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The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements
Src activation is a tightly regulated process which requires RhoB endosome-associated actin assembly and transit to the cell periphery. We show here that although two other ubiquitous Src familyExpand
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Src‐dependent autophagic degradation of Ret in FAK‐signalling‐defective cancer cells
We have recently described that autophagic targeting of Src maintains cancer cell viability when FAK signalling is defective. Here, we show that the Ret tyrosine kinase is also degraded by autophagyExpand
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Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1
We recently reported that a complex between focal adhesion kianse (FAK) and the molecular scaffold RACK1 controlled nascent integrin adhesion formation and cell polarization, via peripheralExpand
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ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival
Summary Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired cell-cell adhesion in skinExpand
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The phospholipid PI(3,4)P2 is an apical identity determinant
Apical-basal polarization is essential for epithelial tissue formation, segregating cortical domains to perform distinct physiological functions. Cortical lipid asymmetry has emerged as a determinantExpand
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