Emma O'Donnell

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Recent findings support a role for ghrelin in the regulation of energy homeostasis and possibly reproductive function. The primary purpose of this study was to test whether differences in fasting ghrelin levels exist in exercising women with differing menstrual and metabolic status. Menstrual cycle status was defined as sedentary ovulatory (SedOvul; n = 10,(More)
The cardiovascular consequences of hypoestrogenism in premenopausal women are unclear. Accordingly, the influence of menstrual status and endogenous estrogen (E(2)) exposure on blood pressure (BP), heart rate (HR), and calf blood flow in young (18-35 yr) regularly exercising premenopausal women with exercise-associated menstrual aberrations was(More)
OBJECTIVE Oestrogen deficiency contributes to altered cardiovascular function in premenopausal amenorrheic physically active women. We investigated whether other energy deficiency-associated factors might also be associated with altered cardiovascular function in these women. DESIGN A prospective observational study was completed at a research facility at(More)
CONTEXT Evidence indicates that hypoestrogenemia is linked with accelerated progression of atherosclerosis. Premenopausal women presenting with ovulatory disruption due to functional hypothalamic amenorrhea (FHA) are characterized by hypoestrogenemia. One common and reversible form of FHA in association with energy deficiency is exercise-associated(More)
BACKGROUND The role of adiponectin in mediating gonadal status and bone health in weight-stable healthy adult female athletes with secondary amenorrhea has not yet been described. METHODS Using a prospective observational study, age-matched premenopausal women were studied, including 1) sedentary ovulatory women (SedOv; n=10), 2) exercising ovulatory(More)
OBJECTIVE We investigated the influence of hormone therapy (HT) on submaximal central and peripheral function in healthy postmenopausal women after 12 weeks of endurance training. METHODS A randomized, double-blind, placebo-controlled study in a research and clinical facility was conducted. All participants (N = 23) underwent 12 weeks of aerobic exercise(More)
Triad: Refuting the IOC Consensus Statement on Relative Energy Deficiency in Sport (RED-S) Mary Jane De Souza, Nancy I Williams, Aurelia Nattiv, Elizabeth Joy, Madhusmita Misra, Anne B Loucks, Gordon Matheson, Marion P Olmsted, Michelle Barrack, Rebecca J Mallinson, Jenna C Gibbs, Marci Goolsby, Jeanne F Nichols, Barbara Drinkwater, Charlotte (Barney)(More)
In premenopausal women, the most severe menstrual dysfunction is amenorrhoea, which is associated with chronic hypoestrogenism. In postmenopausal women, hypoestrogenism is associated with a number of clinical sequelae related to cardiovascular health. A cardioprotective effect of endogenous oestrogen is widely supported, yet recent studies demonstrate a(More)
The renin-angiotensin-aldosterone system (RAAS) is integrally involved in multiple cardiovascular physiological processes including arterial blood pressure (BP) regulation. Over activity of the RAAS has been implicated in the pathogenesis of a number of cardiovascular disease entities, including hypertension. Several lines of evidence suggest estrogen(More)
INTRODUCTION Exercise-trained hypoestrogenic premenopausal women with functional hypothalamic amenorrhea (ExFHA) exhibit impaired endothelial function. The vascular effects of an acute bout of exercise, a potent nitric oxide stimulus, in these women are unknown. METHODS Three groups were studied: recreationally active ExFHA women (n = 12; 24.2 ± 1.2 years(More)