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The mammalian acrosome reaction (AR) is the fusion, at multiple points, of the outer acrosomal membrane with the overlying plasma membrane. This fusion causes the release of acrosomal contents and the exposure of the inner acrosomal membrane. The time taken for this process to occur is not accurately known. Estimates for AR in mouse spermatozoa vary from ϳ2(More)
Low voltage activated, voltage-operated Ca(2+) channels are expressed in rodent male germ cells and are believed to be pivotal in induction of the acrosome reaction in mouse spermatozoa. However, in humans, very little is known about expression of voltage-operated Ca(2+) channels in male germ cells or their function. We have used reverse(More)
Ca2+i signalling is pivotal to sperm function. Progesterone, the best-characterized agonist of human sperm Ca2+i signalling, stimulates a biphasic [Ca2+]i rise, comprising a transient and subsequent sustained phase. In accordance with recent reports that progesterone directly activates CatSper, the [Ca2+]i transient was detectable in the anterior flagellum(More)
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