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BACKGROUND Focal therapy is being offered as a viable alternative for men with localised prostate cancer (PCa), but it is unclear which men may be suitable. OBJECTIVE To determine the proportion of men with localised PCa who are potentially suitable for focal therapy. DESIGN, SETTING, AND PARTICIPANTS Our institutional transperineal template(More)
In this study, we have started to dissect the molecular basis of CD8 dependence of a high and low avidity CTL clone specific for the same peptide epitope. Using anti-CD8alpha and anti-CD8beta antibodies, we found that cytotoxicity and IFN-gamma production by high but not by low avidity CTL was strongly CD8 dependent. We isolated the TCR genes of both types(More)
Thousands of documents written in Syriac script by early Christian theologians are of unknown provenance and uncertain date, partly due to a shortage of human expertise. This paper addresses the problem of attribution by developing a novel algorithm for offline handwriting style identification and document retrieval, demonstrated on a set of documents in(More)
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