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If negative interpretational bias causes emotional vulnerability, reduction of this bias should reduce proneness to anxiety. High trait-anxious volunteers were trained over four sessions to resolve descriptions of ambiguous events in an increasingly positive manner. This group subsequently made more positive interpretations of novel descriptions than did(More)
Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to other post-translational modifications, ubiquitylation is reversible in a process dependent on activity of(More)
Endometriosis is a common chronic gynaecological condition, affecting 5-10% of women of child-bearing age. Its study has been hampered by lack of genetically tractable models. We transplanted steroid-manipulated, menstrual-like endometrium from K-ras(G12V/+) /Ah-Cre(+/+) /ROSA26R-LacZ(+/+) mice into gonad-intact immunocompetent wild-type mice. This led to(More)
Previous research has shown that interpretation biases can be experimentally induced and endure for 24 hours. In two experiments, we show that induced biases not only persist but survive changes in environmental context, including transferring to different rooms with different experimenters. In one experiment, training and testing materials were also(More)
Leukocyte populations change profoundly in the human endometrium during the menstrual cycle. However the predominant cell, the uterine natural killer (uNK) cell does not contain steroid receptors. From gene array analysis we identified a transcript encoding chemokine (C-X-C motif) ligand 14 (CXCL14) which is markedly up-regulated in the secretory phase of(More)
BACKGROUND There have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy such as intra-uterine growth restriction, pre-eclampsia and stillbirth remains largely unchanged. Randomised controlled trials of routine application of high tech screening(More)
The vitamin A metabolite retinoic acid (RA) has been reported to suppress Th1 responses and enhance Th2 responses. Here, we investigated whether differences in vitamin A metabolism could underlie the differences between C57BL/6 and BALB/c mice, which are reportedly seen as Th1 and Th2 responders, respectively. BALB/c mice were shown to have higher(More)
Renal function declines with age and this is more pronounced in males than females. VEGF-A is essential for glomerular development and function but its role in other aspects of renal function is poorly understood. We therefore investigated the role of VEGF-A, derived specifically from haematopoietic and endothelial lineages in the kidney. We crossed VavCre(More)
A new hands-on experiment was devised for science centres to demonstrate EvoFIT, a facial-composite system used by police with witnesses to construct facial likenesses of villains. Visitors watch a video of a man pretending to commit a crime and then construct a composite of his face by repeatedly selecting from an array of faces, with the software(More)
P reeclampsia is one of the most common adverse outcomes of pregnancy. 1 The condition consists of new onset hyper-tension and proteinuria in the second half of pregnancy but can also be superimposed on preexisting hypertension or renal disease. It is associated with increased risks of maternal and perinatal morbidity and mortality. A substantial proportion(More)