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  • Michael E. Fusakio, Jeffrey A. Willy, +5 authors Ronald C Wek
  • Chemistry, Biology, Medicine
  • Molecular biology of the cell
  • 2016 (First Publication: 1 May 2016)
  • Whole-body and liver-specific ATF4–knockout mice are used to evaluate the role of ATF4 transcription factor in the unfolded protein response (UPR). ATF4 directs a small subset of UPR gene expression,Expand
  • Gabriel J. Wilson, Brittany A. Lennox, +7 authors Tracy G Anthony
  • Medicine, Biology
  • American journal of physiology. Endocrinology and…
  • 2015 (First Publication: 15 February 2015)
  • The antileukemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2). ToExpand
  • Lindsey Phillipson-Weiner, Emily T. Mirek, Yongping Wang, W. Geoffrey Mcauliffe, Ronald C Wek, Tracy G Anthony
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal…
  • 2016 (First Publication: 1 June 2016)
  • Treatment with the antileukemic agent asparaginase can induce acute pancreatitis, but the pathophysiology remains obscure. In the liver of mice, eukaryotic initiation factor 2 (eIF2) kinase generalExpand
  • Tracy G Anthony, Emily T. Mirek, +6 authors Ilya Raskin
  • Medicine, Biology
  • Applied physiology, nutrition, and metabolism…
  • 2015 (First Publication: 17 September 2015)
  • Phytoecdysteroids such as 20-hydroxyecdysone (20HE) are nutritional supplements marketed as enhancers of lean body mass. In this study the impact of 20HE ingestion on protein kinase B/Akt-mechanisticExpand
  • Inna A. Nikonorova, Rana Jaber Tarish Al-Baghdadi, +9 authors Tracy G Anthony
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 2017 (First Publication: 27 February 2017)
  • Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress response (ISR) via sensing amino acidExpand
  • Ashley P Pettit, William O Jonsson, +9 authors Tracy G Anthony
  • Biology, Chemistry, Medicine
  • The Journal of nutrition
  • 2017 (First Publication: 1 June 2017)
  • Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stressExpand
  • Inna A. Nikonorova, Emily T. Mirek, Christina C Signore, Michael P Goudie, Ronald C Wek, Tracy G Anthony
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 2018 (First Publication: 15 February 2018)
  • Amino acid availability is sensed by GCN2 (general control nonderepressible 2) and mechanistic target of rapamycin complex 1 (mTORC1), but how these two sensors coordinate their respective signalExpand
  • Rana Jaber Tarish Al-Baghdadi, Inna A. Nikonorova, +5 authors Tracy G Anthony
  • Biology, Medicine, Chemistry
  • Scientific Reports
  • 2017 (First Publication: 28 April 2017)
  • The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective wasExpand