Emily Spellman

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LUZ CAVIEDES, TIEN-SHUN LEE, ROBERT H. GILMAN,* PATRICIA SHEEN, EMILY SPELLMAN, ELLEN H. LEE, DOUGLAS E. BERG, SONIA MONTENEGRO-JAMES, AND THE TUBERCULOSIS WORKING GROUP IN PERU† Department of Pathology, Universidad Peruana Cayetano Heredia, and Asociación Benefica Proyectos en Informatica, Salud, Medicina y Agricultura (AB PRISMA), Lima, Peru; Johns(More)
Inexpensive, rapid, and reliable methods of detecting infection by and drug susceptibility of Mycobacterium tuberculosis (MTB) are crucial to the control of tuberculosis. The novel microscopic observation broth-drug susceptibility assay (MODS) detects early growth of MTB in liquid medium, allowing more timely diagnosis and drug susceptibility testing.(More)
Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. The highest incidence occurs in childhood and in the elderly, with lower levels in early adulthood. Traditional epilepsy management includes pharmacological treatment, epilepsy surgery, and vagal nerve stimulation. Despite these(More)
The 1'-hydroxylation of rac-bufuralol, which is catalyzed by polymorphic CYP2D6 in humans, was studied in brain microsomes from male and female Wistar rats and from the female Dark Agouti rat, a model of the CYP2D6 poor metabolizer phenotype. The kinetics of the 1'-hydroxylation of bufuralol (1-1500 microM) by brain microsomes were biphasic. The activity of(More)
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